23872-55-1

Basic information

• Product Name: 5-{[(4-chlorophenyl)amino]methylidene}pyrimidine-2,4,6(1H,3H,5H)-trione
• Synonyms: 2,4,6(1H,3H,5H)-pyrimidinetrione, 5-[[(4-chlorophenyl)amino]methylene]-; 5-{[(4-Chlorophenyl)amino]methylene}pyrimidine-2,4,6(1H,3H,5H)-trione
• CAS NO: 23872-55-1
• Molecular Formula: C₁₁H₈ClN₃O₃
• Molecular Weight: 265.6525
• Mol File: 23872-55-1.mol
• Article Data: 1

Chemical Properties

• Density: 1.614g/cm³
• Refractive Index: 1.732
• CAS DataBase Reference: 5-{[(4-chlorophenyl)amino]methylidene}pyrimidine-2,4,6(1H,3H,5H)-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{[(4-chlorophenyl)amino]methylidene}pyrimidine-2,4,6(1H,3H,5H)-trione(23872-55-1)
• EPA Substance Registry System: 5-{[(4-chlorophenyl)amino]methylidene}pyrimidine-2,4,6(1H,3H,5H)-trione(23872-55-1)

Safety Data

• Hazardous Substances Data: 23872-55-1(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 

Relevant articles and documents

Computer-aided design, synthesis, and biological evaluation of 5-substituted aminomethylenepyrimidine-2,4,6-triones as H1 antihistaminic agents(Part2)

As a part of a research project pertaining to the synthesis of novel candidates as nonsedating, nonclassic H1 histaminergic (H1) blockers with low toxicity profiles, some new 5-substituted aminomethylenepyrimidine-2,4,6-triones were designed based on the H1 histaminic receptor pharmacophore model. The interactions between the designed compounds and the H1 receptor were studied using molecular docking on the homology model of H1 receptor. The designed compounds were synthesized and biologically evaluated for H1-blocking activity; using isolated segments of guinea pig ileum. Compounds 15,18,19 and 21 exhibited comparable activities to acrivastine (22) as reference nonsedating drug. The C log P of designed compounds revealed lower values in reference to acrivastine (22) which might indicate decreased tendency for crossing the blood brain barrier.