238749-59-2Relevant academic research and scientific papers
Benzofuran based PDE4 inhibitors
McGarry,Regan,Volz,Hulme,Moriarty,Djuric,Souness,Miller,Travis,Sweeney
, p. 1131 - 1139 (2007/10/03)
Replacement of the 3,4-dialkoxyphenyl substructure common to a number of PDE4 inhibitors with a 2-alkyl-7-methoxybenzofuran unit is described. This substitution can result in either enhancement or substantial reductions in PDE4 inhibitory activity depending on the system to which it is applied. An in vitro SAR study of a potent series of 4-(2-heteroaryl-ethyl)-benzofurans 26 is also presented. Copyright (C) 1999 Elsevier Science Ltd.
