23877-12-5

Basic information

• Product Name: t-Butyl 2-bromo isobutyrate
• Synonyms: 2-BOC-2-BROMOPROPANE;2-BROMO-2-METHYL-PROPIONIC ACID TERT-BUTYL ESTER;2-BROMOISOBUTYRIC ACID TERT-BUTYL ESTER;butyl2-bromoisobutyrate;Propanoicacid,2-bromo-2-methyl-,1,1-dimethylethylester;tert-Buty2-bromoisobutyrate;tert-Butyl2-bromoisobutyrate,97%;TERT-BUTYL ALPHA-BROMOISOBUTYRATE
• CAS NO: 23877-12-5
• Molecular Formula: C₈H₁₅BrO₂
• Molecular Weight: 223.11
• EINECS: 245-924-7
• Product Categories: Organic acids
• Mol File: 23877-12-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 35-37°C 1mm
• Flash Point: 35-37°C/1mm
• Appearance: /
• Density: 1.196 g/mL at 20 °C(lit.)
• Vapor Pressure: 1.15mmHg at 25°C
• Refractive Index: n20/D 1.436
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform
• BRN: 1905654
• CAS DataBase Reference: t-Butyl 2-bromo isobutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: t-Butyl 2-bromo isobutyrate(23877-12-5)
• EPA Substance Registry System: t-Butyl 2-bromo isobutyrate(23877-12-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3334
• WGK Germany: 2
• F: 19
• HazardClass: 9
• Hazardous Substances Data: 23877-12-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

tert-Butyl α-bromoisobutyrate was used as an initiator in the atom transfer radical polymerisation (ATRP) of 2-(acetoacetoxy)ethyl methacrylate (AEMA).

InChI:InChI=1/C8H15BrO2/c1-7(2,3)11-6(10)8(4,5)9/h1-5H3

Upstream product

• 115-11-7 isobutene 
• 2052-01-9 2-bromo-2-methylpropionic acid 
• 75-65-0 tert-butyl alcohol 
• 1493-13-6 trifluorormethanesulfonic acid 
• 20769-85-1 2-bromoisobutyric acid bromide 

Downstream Products

• 68672-65-1 imino-2 Z (tritylamino-2 thiazolyl-4)-2 acetate d'ethyle 
• 247923-30-4 1,1-dimethylethyl 2-[(4-bromophenyl)thio]-2-methyl-propanoate 
• 923017-44-1 tert-butyl 2-{2-[(6-chloropyridin-3-yl)carbonyl]-5-methoxyphenoxy}-2-methylpropanoate 
• 923015-53-6 tert-butyl 2-{2-[4-(benzyloxy)benzoyl]-5-methoxyphenoxy}-2-methylpropanoate 
• 638190-18-8 (2S)-3-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-phenyl]-2-ethoxy-propionic acid ethyl ester 
• 848260-83-3 tert-Butyl 2-[2-(aminocarbonylmethyl)phenoxy]-2-methylpropionate 
• 851224-86-7 2-Methyl-2-{4-[3-(4-trifluoromethyl-phenyl)-[1,2,4]thiadiazol-5-ylmethylsulfanyl]-phenoxy}-propionic acid tert-butyl ester 
• 343322-79-2 tert-butyl 2-(4-formylphenoxy)-2-methylpropanoate 
• 627097-15-8 tert-Butyl 2-(3-methoxycarbonylphenoxy)-2-methylpropionate 
• 627096-99-5 tert-Butyl 2-[3-(allyloxycarbonylmethyl)phenoxy]-2-methylpropionate 
• 627097-21-6 tert-Butyl 2-[2-(2-aminocarbonylethyl)phenoxy]-2-methylpropionate 
• 866641-23-8 2-(4-formyl-2-methoxy-6-methylphenoxy)-2-methylpropanoic acid tert-butyl ester 
• 1019680-77-3 tert-butyl 2-(4-(2-methoxy-2-oxoethyl)phenoxy)-2-methylpropanoate 
• 867314-36-1 2-(4-cyanophenylsulfanyl)-2-methyl-propionic acid tert-butyl ester 

Relevant articles and documents

Catalytic synthesis method of tert-butyl alpha-bromoisobutyrate by using cation exchange resin

The invention relates to a catalytic synthesis method of tert-butyl alpha-bromoisobutyrate by using cation exchange resin, and belongs to the technical field of synthetic organic chemistry synthesis. The method use alpha-bromoisobutyrate and isobutylene as raw materials; the raw materials are supplemented with a solvent and a polymerization inhibitor and subjected to an esterification reaction by using a cation exchange resin as a catalyst, so as to obtain the tert-butyl alpha-bromoisobutyrate. The cation exchange resin is one or more selected from D001, D003, CH-A, CH-B, 732, and CHR-06. The invention solves the problems of large amount of wastewater, serious equipment corrosion and high content of polymer in the prior art; the prepared product has yield of 80-90% and purity higher than 98%; and the selected cation exchange resin has the characteristics of high catalytic activity, good selectivity, small equipment corrosion, long service life, easiness to recycle and reuse, low energy consumption and less wastewater generation, and has high economic values for reducing production costs, safety and environmental protection.

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