23877-63-6

Upstream product

• 108-22-5 Isopropenyl acetate 
• 873-32-5 2-Chlorobenzonitrile 
• 2042-37-7 o-cyanobromobenzene 
• 91054-33-0 2-acetylbenzonitrile 
• 19493-09-5 Methylenetriphenylphosphorane 
• 14559-87-6 isopropenylboronic acid 

Relevant academic research and scientific papers

Chiral Aluminum Complex Controls Enantioselective Nickel-Catalyzed Synthesis of Indenes: C?CN Bond Activation

A chiral aluminum complex controlled, enantioselective nickel-catalyzed domino reaction of aryl nitriles and alkynes proceeding by C?CN bond activation was developed. The reaction provides various indenes, bearing chiral all-carbon quaternary centers, under mild reaction conditions in yields of 32 to 91 percent and ee values within the 73–98 percent range. The reaction mechanism and aspects of stereocontrol were investigated by DFT calculations.

Synthesis of (Z)-2-(2H-isoquinolin-1-ylidene)acetamides by iodine-mediated cyclization of (Z)-3-amino-3-(2-vinylphenyl)propenamides

(Z)-2-(2-Acetyl-2H-isoquinolin-1-ylidene)acetamides have been synthesized from 2-vinylbenzonitrile derivatives in three steps. The key step involves the iodine-mediated 6-endo cyclization of (Z)-3-acetylamino-3-(2-vinylphenyl) propenamides, which are prep

Cobalt-catalyzed vinylation of functionalized aryl halides with vinyl acetates

A new method for the preparation of styrene derivatives is described on the basis of the activation of aryl halides by low-valent cobalt species. A combination of CoII bromide and 2,2′-bipyridine is suitable as catalyst for the cross-coupling reaction of a wide range of aromatic halides (X = Cl, Br, I), mostly bearing sensitive moieties, with vinyl acetates. These reactions proceed under mild conditions in the presence of the appropriate reducing agent to afford α-substituted styrene compounds in satisfactory to high yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.

Suzuki cross-coupling reactions between alkenylboronic acids and aryl bromides catalysed by a tetraphosphane-palladium catalyst

A range of alkenylboronic acids undergo Suzuki cross-coupling with aryl bromides in good yields in the presence of [PdCl(C3H 5)]2/cis,cis,cis-1,2,3,4-tetrakis[(diphenylphosphanyl) methyl]cyclopentane as a catalyst. A wide variety of 1-arylprop-1-enes, 2-arylprop-1-enes, 2-arylbut-1-enes and 1,1-diarylethylene or styrene derivatives have been prepared. Moreover, the reaction tolerates several functions, such as acetyl, formyl, nitrile or nitro. Furthermore, this catalyst can be used at low loading, even for reactions of sterically hindered substrates. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Process of heterocoupling by electrolytic microbattery, use of cobalt for implementing said coupling and composition for doing so

This invention has as its object a process for preparation of vinyl aryl derivatives by an electrochemical path. This process is defined in that it consists in subjecting a composition that comprises a cobalt salt, an aromatic halide and a vinyl ester to the action of a metal that is at least as reducing as zinc. Application to organic synthesis.