23894-46-4

Usage

Family

Pyrrole family

Structure

Five-membered ring with one nitrogen atom, three methyl groups, and two phenyl groups attached

Physical state

Pale yellow crystalline solid at room temperature

Field of use

Organic chemistry

Applications

Building block in the synthesis of other compounds, reagent in various chemical reactions

Potential uses

Pharmaceutical and medicinal

Biological activities

Antimicrobial and antifungal properties

Upstream product

• 16602-83-8 phenyl-acetone-methylhydrazone 
• 103-79-7 1-phenyl-acetone 

Downstream Products

• 115695-78-8 C₄₆H₄₄N₂ 

Relevant academic research and scientific papers

Reaction of Ketone Alkylhydrazones with Phosphorus Trichloride: a General Mild Route to Substituted Pyrroles

A new convinient and mild procedure for the synthesis of symmetrically and unsymmetrically substituted pyrroles is described.This one-pot synthesis consists of two different stages.The first stage, addition of PCl3 to an alkylhydrazone, is always carried out at room temperature.The second stage, addition of an enolizable ketone to the previous reaction mixture, is performed at room temperature, or at 80 deg C under reduced pressure.The results provide clear evidence that diazaphsphole derivatives being formed in the first stage are intermediates in this pyrrole synthesis.

Synthesis of Pyrroles under Mild Conditions using PCl3, Ketones, and Alkylhydrazines

A one-pot synthesis of symmetrical pyrroles was obtained by reaction of alkylhydrazones of enolizable ketones, PCl3, and subsequent addition of the same ketone.