23902-03-6Relevant academic research and scientific papers
Easy and efficient copper-catalyzed synthesis of bicyclic pyrimidinones under mild conditions
Guo, Qi,Yang, Haijun,Liu, Hongxia,Jiang, Yuyang,Fu, Hua
experimental part, p. 2611 - 2616 (2010/11/24)
A simple and efficient copper-catalyzed method has been developed for synthesis of bicyclic pyrimidinones containing six-, seven-, eight-membered rings under mild conditions. The protocol uses readily available 2-bromocycloalk-1-enecarboxylic acids, amidines, and guanidines as the starting materials, copper-catalyzed cascade couplings provide the corresponding bicyclic pyrimidinones without addition of any ligand or additive, and the method is of economical and practical advantages. Georg Thieme Verlag Stuttgart New York.
SATURATED HETEROCYCLES, XLVI SYNTHESIS OF 2-SUBSTITUTED-5,6-PENTAMETHYLENE-, 5,6-HEXAMETHYLENE- AND 5,6-DECAMETHYLENEPYRIMIDIN-4(3H)-ONES
Bernath, G.,Lazar, J.,Gera, L.,Goendoes, Gy.,Ecsery, Z.
, p. 231 - 236 (2007/10/02)
By the reactions of cycloheptanone-, cyclooctanone- and cyclodecanone-β-carboxylic esters and appropriate alkyl- or substituted aryl- and aralkyl amidines, several 2-substituted-5,6-pentamethylene-, 5,6-hexamethylene- and 5,6-decamethylenepyrimidin-4(3H)-one derivatives have been synthesized for pharmacological tests.
