23903-57-3

Usage

Uses

Used in Research Applications:
Dihydroorotate Acid Methyl Ester is used as a chemical reagent for dihydroorotate dehydrogenase (DHODH) related research. It serves as a valuable tool for scientists to investigate the function and regulation of DHODH enzyme, which plays a crucial role in the de novo pyrimidine biosynthesis pathway.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Dihydroorotate Acid Methyl Ester is utilized as a starting material or intermediate in the synthesis of various drugs targeting DHODH enzyme. Inhibiting DHODH has been shown to have potential therapeutic benefits in treating certain diseases, making Dihydroorotate Acid Methyl Ester an important component in drug development processes.
Used in Biochemical Assays:
Dihydroorotate Acid Methyl Ester is also employed in biochemical assays to measure the activity of DHODH enzyme. By using Dihydroorotate Acid Methyl Ester as a substrate, researchers can accurately determine the enzyme's activity levels, which can be useful in understanding its role in various biological processes and disease states.
Overall, Dihydroorotate Acid Methyl Ester is a versatile chemical reagent with applications in research, pharmaceutical development, and biochemical assays, all centered around the study and manipulation of the dihydroorotate dehydrogenase enzyme.

Upstream product

• 116393-69-2 methyl N³-benzyloxymethyl-5,6-dihydroorotate 
• 116393-68-1 methyl N¹,N³-dibenzyloxymethyl-5,6-dihydroorotate 
• 155-54-4 4,5-dihydroorotic acid 

Relevant academic research and scientific papers

2-oxo-4-carboxy-pyrimidines and their use as anti-malaria and anti-cancer agents

A compound for use as an inhibitor for the enzyme dihydroorotase and which is of general formula (I) STR1 where either (i) A and B together are =S or (ii) A is --H, and B is --COR2 or --SR6 ; and R1 and R2 which may be the same or different are --OH; alkyloxymethyl, a di-, tri- or polypeptide group, --OR where R is saturated or unsaturated C1-16 alkyl, C1-16 alkyloxymethyl, or 4-alkyl-piperidinyl-alkyl, --NR'R' where each R' is independently selected from --H, saturated or unsaturated C1-16 alkyl, or any group above to be hydrolyzed in vivo to hydroxy; R3 and R4 which may be the same or different are --H, C1-6 alkyl, hydroxy C1-16 alkyl, hydroxy C1-6 ether group, tetrahydrofuranyl, tetrahydropyranyl, a sugar or acetylated sugar group, hexylcarbamyl, methylglycine-N-carbonyl, or any group able to be hydrolyzed in vivo to --H; R5 is --H, halo, or C1-6 alkyl; R6 is C1-6 alkyl or 1-methyl-4-nitroimidazol-5-yl; and the dotted line represents a double bond which may be absent or present in the 4-5 position. The compounds are useful as anti-cancer and anti-malarial drugs.

2-Oxo-4-carboxy-pyrimidines

A compound for use as an inhibitor for the enzyme dihydroorotase and which is of general formula (I) where either (i) A and B together are =S, or (ii) A is -H, and B is -COR2 or -SR6; and, R1 and R2 which may be the same or different are -OH; alkyloxymethyl, a di-, tri- or polypeptide group, -OR where R is saturated or unsaturated C1-16alkyl, C1-16alkyloxymethyl, or 4-alkyl-piperidinyl-alkyl, -NR′R′ where each R′ is independently selected from -H, saturated or unsaturated C1-16alkyl, or any group able to be hydrolysed in vivoto hydroxy;, R3 and R4 which may be the same or different are -H, C1-6alkyl, hydroxy C1-16alkyl, hydroxy C1-6ether group, tetrahydrofuranyl, tetrahydropyranyl, a sugar or acetylated sugar group, hexylcarbamyl, methylglycine-N-carbonyl, or any group able to be hydrolysed in vivoto -H;, R5 is -H, halo, or C1-6alkyl;, R6 is C1-6alkyl or 1-methyl-4-nitroimidazol-5-yl; and the dotted line represents a double bond which may be absent or present in the 4-5 position. The compounds are useful as anti-cancer and anti-malarial drugs.

A SELECTIVE AND EFFICIENT METHOD FOR THE DEPROTECTION OF N-BENZYLOXYMETHYL (BOM) PROTECTING GROUPS FROM PYRIMIDINE AND DIHYDROPYRIMIDINE RING SYSTEMS

N1,N3-dibenzyloxymethyl derivatives of pyrimidines and dihydropyrimidines have been successfully deprotected by using trifluoroacetic acid (TFA).These N-BOM derivatives can be selectively removed from a variety of derivatives including nucleosides and compounds which are sensitive to base and reducing conditions.