23905-46-6

Basic information

• Product Name: 3-ACETYLAMINO-BENZENESULFONYL CHLORIDE
• Synonyms: AKOS AKM01277;3-(acetylamino)benzenesulfonyl chloride(SALTDATA: FREE);3-ACETYLAMINO-BENZENESULFONYL CHLORIDE;CHEMBRDG-BB 4001989;3-acetamidobenzene-1-sulfonyl chloride
• CAS NO: 23905-46-6
• Molecular Formula: C₈H₈ClNO₃S
• Molecular Weight: 233.67
• Mol File: 23905-46-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 437.1°C at 760 mmHg
• Flash Point: 218.1°C
• Appearance: /
• Density: 1.468g/cm³
• Vapor Pressure: 7.71E-08mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-ACETYLAMINO-BENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ACETYLAMINO-BENZENESULFONYL CHLORIDE(23905-46-6)
• EPA Substance Registry System: 3-ACETYLAMINO-BENZENESULFONYL CHLORIDE(23905-46-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 23905-46-6(Hazardous Substances Data)

Usage

General Description

3-Acetylamino-Benzenesulfonyl Chloride, also known as N-acetylbenzenesulfonyl chloride or 2243-30-1, is a chemical compound commonly used in organic synthesis. It contains nitrogen, hydrogen, chlorine, and sulfur, and belongs to the family of organic compounds known as aniline and substituted anilines. It is generally characterized as a pale brown to red crystalline powder. However, detailed information about its hazard, toxicity, and safety handling is not readily available, indicating that further research and experiments are needed to fully understand the complex nature of this chemical.

InChI:InChI=1/C8H8ClNO3S/c1-6(11)10-7-3-2-4-8(5-7)14(9,12)13/h2-5H,1H3,(H,10,11)

Upstream product

• 121-47-1 3-aminobenzenesulfonic acid 
• 103-84-4 Acetanilid 
• 10026-13-8 phosphorus pentachloride 
• 54981-39-4 3-acetamidobenzenesulfonic acid 

Downstream Products

• 23905-47-7 bis-(3-acetylamino-phenyl)-disulfide 
• 23010-42-6 3-acetylamino-benzenesulfonic acid amide 
• 91170-70-6 3-acetylamino-benzenesulfinic acid 
• 85169-25-1 3-acetylamino-benzenesulfonic acid anilide 
• 80-21-7 1-aminobenzene-3-sulphonic acid phenylamide 
• 143173-93-7 3-amino-N-butyl-benzenesulfonamide 
• 1346113-76-5 N-(3-(N-(3,4-dimethylphenyl)sulfamoyl)phenyl)acetamide 
• 1245240-38-3 C₁₆H₁₈N₂O₅S 
• 1245240-36-1 C₁₆H₁₈N₂O₅S 
• 1245240-37-2 C₁₆H₁₈N₂O₃S 
• 1245240-41-8 C₁₄H₁₁BrF₂N₂O₃S 

Relevant articles and documents

N - aryl sulfonamide compound, its pharmaceutical composition and its use (by machine translation)

The invention discloses a category represented by the following general formula I N - aryl sulfonamide compound, to the compound as the active ingredient of the pharmaceutical composition, and their preparation for treating Lp - PLA2 In the diseases related to the activity of the use. (by machine translation)

Design, synthesis and pharmacological evaluation of indolylsulfonamide amines as potent and selective 5-HT6 receptor antagonists

A series of N′-[3-(indole-1-sulfonyl) aryl]-N,N-dimethyl ethane-1,2-diamines and N′-[3-(indole-1-sulfonyl) aryl]-N,N-dimethyl propane-1,3-diamines was designed and synthesized as 5-HT6 receptor ligands. These compounds, when screened in a functional reporter gene-based assay, displayed potent antagonistic activity with Kb values in the range of 1.8-60 nM. The lead compound 9y has shown good ADME surrogate properties, acceptable pharmacokinetic profile and is active in animal models of cognition like novel object recognition test and Morris water maze. It was selected for detailed profiling.

SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE

The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.