239078-59-2

Upstream product

• 239078-57-0 tert-butyl-(1,5-dimethylhex-4-enyloxy)diphenylsilane 
• 289477-69-6 4-(tert-butyl-diphenyl-silanyloxy)-pentanal 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 4630-06-2 6-methylhept-5-en-2-ol 
• 239078-58-1 6-(tert-butyldiphenylsilanyloxy)-2-methylhept-2(E)-enoic acid ethyl ester 

Downstream Products

• 239078-61-6 (6-benzenesulfonyl-1,5-dimethylhex-4(E)-enyloxy)-tert-butyldiphenylsilane 
• 239078-62-7 3(R)-(2-benzenesulfonyl-7-hydroxy-3-methyloct-3(E)-enyl)-2,2-dimethylcycloprpane-1(R)-carboxylic acid tert-butyl ester 
• 239078-60-5 (6-bromo-1,5-dimethylhex-4(E)-enyloxy)-tert-butyldiphenylsilane 

Relevant academic research and scientific papers

Total synthesis and absolute configuration of (-)-anthoplalone

We report the total synthesis of the cytotoxic agent (-)-anthoplalone and the determination of its absolute stereochemistry. The cyclopropane moiety was prepared using a nonracemic bicyclic chloroallyl phosphonamide anion addition to tert-butyl 3,3-dimethyl acrylate. Several pathways were studied to secure the E-trisubstituted olefin of the left part of the molecule.