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Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-4-(trifluoromethyl)phenylacetonitrile is used as a key intermediate in the synthesis of various drugs, including antivirals and anti-inflammatory agents. Its unique structure contributes to the development of new therapeutic agents that can address specific medical needs.
Used in Agrochemical Industry:
In the agrochemical field, 2-Fluoro-4-(trifluoromethyl)phenylacetonitrile serves as a precursor in the creation of compounds that can be utilized in crop protection and pest management, enhancing agricultural productivity and crop safety.
Used in Chemical Research and Development:
2-Fluoro-4-(trifluoromethyl)phenylacetonitrile is also employed as a reagent in chemical research and development, aiding scientists in exploring new chemical reactions and advancing the understanding of organic chemistry.
Safety Note:
It is crucial to handle 2-Fluoro-4-(trifluoromethyl)phenylacetonitrile with care due to its potential hazards. 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLACETONITRILE can be harmful if inhaled, swallowed, or comes into contact with the skin, necessitating proper safety measures during its use.

InChI:InChI=1/C9H5F4N/c10-8-5-7(9(11,12)13)2-1-6(8)3-4-14/h1-2,5H,3H2

Upstream product

• 32137-19-2 1,2-difluoro-4-(trifluoromethyl)benzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 1257088-54-2 [2-fluoro-4-(trifluoromethyl)phenyl]acetaldehyde oxime 
• 1257088-55-3 ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate 

Downstream Products

• 1187227-36-6 5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine 
• 1187227-34-4 4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-benzenesulfonamide 
• 1314700-27-0 1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropanecarbonitrile 
• 1115300-64-5 4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-yl]-benzenesulfonamide 
• 1115300-70-3 5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-phenyl)-3H-[1,2,3]triazol-4-ylamine 
• 885068-05-3 2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamine hydrochloride 
• 771583-82-5 2-[2-fluoro-4-(trifluoromethyl)phenyl]ethanamine 
• 885068-26-8 {6-[3-(2-amino-ethyl)-phenyl]-2-methoxy-pyrimidin-4-yl}-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethyl]-amine 
• 885068-25-7 (3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-acetonitrile 
• 885068-30-4 3-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol 
• 885068-04-2 (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethyl]-amine 
• 885068-03-1 (5-{6-[2-(2-fluoro-4-trifluoromethyl-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-1H-indol-3-yl)-acetic acid 

Relevant academic research and scientific papers

N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Efficient methods for the synthesis of arylacetonitriles

Various approaches to [2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile were investigated. Two of these methods were selected and applied to a variety of electron-deficient substrates, thereby expanding the scopes of the procedures.