23913-55-5

Usage

Also known as

1-amino-1-naphthalenyl ethanol

Structure

naphthalene ring with a hydroxyl group and an amino group attached

Uses

Chiral auxiliary in pharmaceutical industry for synthesis of drugs with antihistaminic and anti-inflammatory properties
Building block in organic synthesis for various compounds
Potential precursor for production of dyes and pigments

Safety

must be handled with care and proper safety protocols followed due to potential health hazards.

Upstream product

• 83575-57-9 2-(naphthalen-1-yl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 53773-37-8 2-amino-1-(1-naphthyl)ethanone hydrochloride 
• 121950-19-4 1-naphthyl cyanohydrin 
• 66-77-3 1-naphthaldehyde 
• 102309-21-7 N-(2-hydroxy-2-[1]naphthyl-ethyl)-acetamide 

Downstream Products

• 102090-24-4 1,1-dimethylethyl [2-hydroxy-2-(1-naphthalenyl)ethyl]carbamate 

Relevant academic research and scientific papers

Catalyst-Free Electrophilic Ring Expansion of N-Unprotected Aziridines with α-Oxoketenes to Efficient Access 2-Alkylidene-1,3-Oxazolidines

2-(2-Oxoalkylidene)-1,3-oxazolidine derivatives were synthesized in good to excellent yields regiospecifically through the catalyst-free electrophilic ring expansion of N-unprotected aziridines and the ketene C=O double bond of α-oxoketenes, in situ generated from the microwave-assisted Wolff rearrangement of 2-diazo-1,3-diketones. The ring expansion predominantly underwent an SN1 process and the hydrogen bond decides the (E)-configuration of products. (Figure presented.).

INHIBITORS OF AKT ACTIVITY

Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.