239136-18-6

Upstream product

• 558-13-4 carbon tetrabromide 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 1446516-83-1 1-chloro-4-(3,4-dibromo-1,1,1-trifluorobut-2-en-2-yl)benzene 
• 1446516-87-5 1-chloro-4-(3,4-dibromo-1,1,1-trifluorobut-2-en-2-yl)benzene 
• 1446516-77-3 (E)-1-(3-bromo-1,1,1-trifluorobut-2-en-2-yl)-4-chlorobenzene 
• 204071-05-6 5,6,7,8-tetra-p-chlorophenyl-5,6,7,8-tetrakis(trifluoromethyl)[4]radialene 

Relevant academic research and scientific papers

Ruthenium catalyzed reductive coupling of paraformaldehyde to trifluoromethyl allenes: CF3-bearing all-carbon quaternary centers

Trifluoromethyl substituted allenes engage in ruthenium catalyzed reductive couplings with paraformaldehyde to form products of hydrohydroxymethylation as single regioisomers. This method enables generation of CF3-bearing all-carbon quaternary

Re-investigation of the coupling reaction of 2-aryl-1,1-dibromo-3,3,3- trifluoropropenes. Preparation of perfluoroalkylated [3]cumulenes

The coupling reaction of perfluoroalkylated 2-aryl-1,1-dibromoalkenes using zinc and copper(1) bromide gave stereoisomeric mixtures of [3]cumulenes and [4]radialenes. The ratio of [3]cumulenes and [4]radialenes mainly depended upon the reaction temperature and the electronic character of the aryl group. When the coupling reaction was carried out at -40 °C, (E)- and (Z)-[3]cumulenes were obtained in good selectivity and only trace amounts of [4]radialenes were detected by a 19FNMR analysis. On the other hand, a similar reaction at -60 °C afforded a considerable amount of [4]radialene isomers. When the cis-[3]cumulenes were heated at an appropriate temperature, selective isomerization to trans-[3]cumulenes occurred.