239137-42-9Relevant articles and documents
TRICYCLIC CRBN LIGANDS AND USES THEREOF
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Paragraph 0755; 0756, (2020/01/24)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
Ultrasound assisted one-pot synthesis of 1,2-diaryl azaindoles via Pd/C-Cu catalysis: Identification of potential cytotoxic agents
Dandela, Rambabu,Nath Singh, Shambhu,Pal, Manojit,Ramamohan, Hindupur,Siddaiah, Vidavalur,Venkateshwarlu, Rapolu
supporting information, (2019/11/28)
Ultrasound assisted one-pot and direct access to 1,2-diaryl substituted azaindole derivatives has been achieved via the sequential N-arylation followed by coupling-cyclization under Pd/C-Cu catalysis. The methodology involved initial C[sbnd]N bond forming
Synthesis of Substituted 4-, 5-, 6-, and 7-Azaindoles from Aminopyridines via a Cascade C-N Cross-Coupling/Heck Reaction
Pires, Marina J. D.,Poeira, Diogo L.,Purifica?ao, Sara I.,Marques, M. Manuel B.
supporting information, p. 3250 - 3253 (2016/07/13)
A practical palladium-catalyzed cascade C-N cross-coupling/Heck reaction of alkenyl bromides with amino-o-bromopyridines is described for a straightforward synthesis of substituted 4-, 5-, 6-, and 7-azaindoles using a Pd2(dba)3/XPhos/t-BuONa system. This procedure consists of the first cascade C-N cross-coupling/Heck approach toward all four azaindole isomers from available aminopyridines. The scope of the reaction was investigated and several alkenyl bromides were used, allowing access to different substituted azaindoles. This protocol was further explored for N-substituted amino-o-bromopyridines.
