2393-58-0

Basic information

• Product Name: (3a,5b,6b,7a)-3,6,7-trihydroxy-Cholan-24-oic acid
• Synonyms: (3a,5b,6b,7a)-3,6,7-trihydroxy-Cholan-24-oic acid;a-Muricholic acid;alpha-Muricholate;DKPMWHFRUGMUKF-GDYCBZMLSA-N
• CAS NO: 2393-58-0
• Molecular Formula: C₂₄H₄₀O₅
• Molecular Weight: 408.57
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 2393-58-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 200-202 °C
• Boiling Point: 565.7°Cat760mmHg
• Flash Point: 310°C
• Appearance: /
• Density: 1.184g/cm³
• Vapor Pressure: 3.75E-15mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 4.76±0.10(Predicted)
• CAS DataBase Reference: (3a,5b,6b,7a)-3,6,7-trihydroxy-Cholan-24-oic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3a,5b,6b,7a)-3,6,7-trihydroxy-Cholan-24-oic acid(2393-58-0)
• EPA Substance Registry System: (3a,5b,6b,7a)-3,6,7-trihydroxy-Cholan-24-oic acid(2393-58-0)

Safety Data

• Hazardous Substances Data: 2393-58-0(Hazardous Substances Data)

Usage

Description

α-Muricholic acid is a murine-specific primary bile acid. Dietary administration of soybean protein decreases fecal levels of α-muricholic acid in mice with high-fat diet-induced obesity which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids. Plasma, liver, and muscle levels of α-muricholic acid are increased in mice switched from a high-fat to low-fat diet.

Uses

α-Muricholic Acid is an bile acid found in urine. Studies have linked α-Muricholic in the understanding of the complex signaling pathways of hepatic lipid abnormalities with type 2 diabetes and a treatment target for this condition.

InChI:InChI=1/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13?,14-,15?,16?,17?,18+,20?,21+,22+,23-,24-/m1/s1