23945-54-2Relevant academic research and scientific papers
Hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of thioethers and ethers from quinazolin-4(3H)-ones
Hu, Baoxiang,Zhang, Xiaochu,Sheng, Lili,Guo, Ming,Shen, Zhenlu,Hu, Xinquan,Sun, Nan,Mo, Weimin
, p. 5580 - 5593 (2013/07/04)
A hexachlorocyclotriphosphazene (HCCP)-mediated direct formation of quinazoline (thio)ethers from quinazolin-4(3H)-ones has been developed. Treatment of quinazolin-4(3H)-ones with HCCP, diisopropylethylamine (DIPEA), and thiophenols resulted in formation of the corresponding 4-arylthioquinazoline derivatives in moderate to excellent yields. This method has also been utilized to prepare 4-aryloxyquinazoline and 4-alkoxyquinazoline derivatives using phenols and sodium alkoxides as the nucleophiles.
4-Thiophenoxy-2-trichloromethyquinazolines display in vitro selective antiplasmodial activity against the human malaria parasite Plasmodium falciparum
Verhaeghe, Pierre,Dumtre, Aurélien,Castera-Ducros, Caroline,Hutter, Sébastien,Laget, Michle,Fersing, Cyril,Prieri, Marion,Yzombard, Julien,Sifredi, France,Rault, Sylvain,Rathelot, Pascal,Vanelle, Patrice,Azas, Nadine
experimental part, p. 6003 - 6006 (2011/10/09)
A series of original quinazolines bearing a 4-thiophenoxy and a 2-trichloromethyl group was synthesized in a convenient and efficient way and was evaluated toward its in vitro antiplasmodial potential. The series revealed global good activity against the
