23947-41-3Relevant articles and documents
A comparative study of synthetic approach to 1-methyl-2,5,8(1H)-quinolinetrione and 4-methyl-2,5,8(1H)-quinolinetrione
Avendano,De la Cuesta,Gesto
, p. 727 - 730 (1991)
The best overall yield for 1-methyl-2,5,8(1H)-quinolinetrione was obtained by the dichromate oxidation of 1-methyl-8-hydroxy-2-quinolone. 4-Methyl-2,5,8(1H)-quinolinetrione was synthesized by acetoacetylation of 2,5-dimethoxyaniline with 2,2,6-trimethyl-4H-1,3-dioxin-4-one followed by oxidation with ceric ammonium nitrate.
Synthesis of carbon-11-labeled casimiroin analogues as new potential PET agents for imaging of quinone reductase 2 and aromatase expression in breast cancer
Wang, Min,Gao, Mingzhang,Miller, Kathy D.,Sledge, George W.,Hutchins, Gary D.,Zheng, Qi-Huang
experimental part, p. 967 - 973 (2010/10/05)
Carbon-11-labeled casimiroin analogues were first designed and synthesized as new potential PET agents for imaging of quinone reductase (QR) 2 and aromatase expression in breast cancer. [11C]casimiroin (6-[ 11C]methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one, [ 11C]11) and its carbon-11-labeled analogues 5,6,8-trimethoxy-1-[ 11C]methyl-4-methylquinolin-2(1H)-one ([11C]17), 8-methoxy-1-[11C]methyl-4-methylquinolin-2(1H)-one ([ 11C]21a), 6,8-dimethoxy-1-[11C]methyl-4-methylquinolin- 2(1H)-one ([11C]21b), and 5,8-dimethoxy-1-[11C]methyl-4- methylquinolin-2(1H)-one ([11C]21c), were prepared from their corresponding precursors with [11C]methyl triflate ([ 11C]CH3OTf) under basic conditions (NaH) through either O- or N-[11C]methylation and isolated by semi-preparative HPLC method in 40-50% radiochemical yields decay corrected to end of bombardment (EOB), based on [11C]CO2, and 111-185 GBq/μmol specific activity at the end of synthesis (EOS).
Antimalarial 6 aminoquinolines. V. 2-, 3-, and 4-mono-, di-, and trimethyl derivatives of 6 (4 diethylamino 1 methylbutylamino) 5,8 dimethoxyquinoline
Nickel,Fink
, p. 367 - 382 (2007/10/04)
-