239476-79-0Relevant articles and documents
Catalytic Asymmetric Cyclocarbonylation of Nitrogen-Containing Enynes
Sturla, Shana J.,Buchwald, Stephen L.
, p. 5547 - 5550 (1999)
The asymmetric Pauson-Khand type cyclization of nitrogen-containing enynes using carbon monoxide and a catalytic amount of (EBTHI)TiMe2 was examined. The influence of the nitrogen substituent and the concentration of the catalyst on the enantioselectivity of this cyclization was explored, and it has been found that enynes with an octyl-, benzyl-, or allylamino group, positioned β to the alkyne and the olefin, are cyclized with a high degree of enantioselectivity. Substrates with either bulky and/or electron-withdrawing nitrogen substituents are converted to products in low to moderate enantioselectivity.
