23961-95-7

Basic information

• Product Name: 9beta,11beta-epoxy-6alpha-fluoro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
• Synonyms: 9beta,11beta-epoxy-6alpha-fluoro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione;9β,11β-Epoxy-6α-fluoro-17,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione;(4aS,4bS,5aS,6aS,7R,8R,9aS,9bS,11S)-11-fluoro-7-hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-trimethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one(WXG01285);(4aS,4bS,5aS,6aS,7R,8R,9aS,9bS,11S)-11-fluoro-7-hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-trimethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
• CAS NO: 23961-95-7
• Molecular Formula: C₂₂H₂₇FO₅
• Molecular Weight: 390.4451832
• EINECS: 245-956-1
• Mol File: 23961-95-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 566.6°Cat760mmHg
• Flash Point: 296.5°C
• Appearance: /
• Density: 1.36g/cm³
• CAS DataBase Reference: 9beta,11beta-epoxy-6alpha-fluoro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 9beta,11beta-epoxy-6alpha-fluoro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione(23961-95-7)
• EPA Substance Registry System: 9beta,11beta-epoxy-6alpha-fluoro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione(23961-95-7)

Safety Data

• Hazardous Substances Data: 23961-95-7(Hazardous Substances Data)

Upstream product

• 4571-51-1 9β,11-epoxy-6α-fluoro-16α-methyl-17,21-dihydroxy-1,4-diene-3,20-dione 21-acetate 
• 24916-90-3 17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione 

Downstream Products

• 2607-06-9 6α,9-difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 
• 2135-17-3 flumetasone 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS

The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone or Desoximetasone.

16α-methylation process

Disclosed is a process for the production of a Δ17(20) -steroid of the formula STR1 which comprises starting with a 16-unsaturated corticoid of the formula STR2 and contacting the 16-unsaturated corticoid (I) with a methylating agent in the presence of a copper catalyst and a silylating agent.

Process for the preparation of 6-halo-pregnanes

The invention relates to a new process for the preparation of 6α-halo-3-keto-Δ1,4 -pregnadiene-derivatives in two-steps-synthesis affording directly 6α-halo-derivatives by reacting 3-keto-9β,11β-oxido-Δ1,4 -pregnadiene-derivatives with a suitable acylating or etherifying agent to give the corresponding new 3-enol-derivatives which are finally halogenated by using a suitable halogenating agent.