23965-11-9

Basic information

• Product Name: 6-bromo-3-phenyl-2,4(1H,3H)-quinazolinedione
• Synonyms: 6-bromo-3-phenyl-2,4(1H,3H)-quinazolinedione;6-bromo-3-phenyl-1H-quinazoline-2,4-dione;6-bromo-3-phenyl-1H-quinazoline-2,4-quinone;6-bromo-3-phenylquinazoline-2,4(1H,3H)-dione
• CAS NO: 23965-11-9
• Molecular Formula: C₁₄H₉BrN₂O₂
• Molecular Weight: 317.15
• Mol File: 23965-11-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 254-255 °C(Solv: isopropanol (67-63-0); N,N-dimethylformamide (68-12-2))
• Appearance: /
• Density: 1.612±0.06 g/cm3(Predicted)
• PKA: 11.25±0.20(Predicted)
• CAS DataBase Reference: 6-bromo-3-phenyl-2,4(1H,3H)-quinazolinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-3-phenyl-2,4(1H,3H)-quinazolinedione(23965-11-9)
• EPA Substance Registry System: 6-bromo-3-phenyl-2,4(1H,3H)-quinazolinedione(23965-11-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 23965-11-9(Hazardous Substances Data)

Usage

General Description

6-bromo-3-phenyl-2,4(1H,3H)-quinazolinedione is a chemical compound with a molecular formula of C15H9BrN2O2. It is a quinazoline derivative and contains a bromine atom and a phenyl group. 6-bromo-3-phenyl-2,4(1H,3H)-quinazolinedione has potential applications in medicinal chemistry and drug development due to its reported biological activities, such as anticancer and anti-inflammatory properties. It may also be used in organic synthesis and as a building block for the synthesis of other compounds. 6-bromo-3-phenyl-2,4(1H,3H)-quinazolinedione has molecular weight of 331.15 g/mol and a melting point of 320-322 °C. Further research on this chemical may reveal additional potential uses and properties.

Upstream product

• 4692-98-2 5-bromoisatoic anhydride 
• 62-53-3 aniline 
• 371116-19-7 C₁₅H₁₃BrN₂O₃ 
• 18009-07-9 6-bromo-2-mercapto-3-phenylquinazolin-4(3H)-one 

Downstream Products

• 925141-07-7 6-bromo-3-phenyl-1-(4-chlorobenzyl)quinazoline-2,4(1H,3H)-dione 

Relevant articles and documents

Design, synthesis, and biological evaluation of triazolyl- and triazinyl-quinazolinediones as potential antitumor agents

Novel 6(3-1H-1,2,4-triazol-1-yl)-3-phenylquinazoline-2,4(1H,3H)-diones (7a-e) were synthesized from different enaminones (6a-e) with 6-hydrazinyl-3-phenylquinazoline-2,4(1H,3H)-dione. 2,6(4-2-Substituted-1,3,5-triazin-1(2H)-yl)-3-phenylquinazoline-2,4(1H,3H)-diones (8a-k) were synthesized from the reaction of 1-(2,4-dioxo-3-phenyl-1,2,3,4-tetrahydroquinazolin-6-yl)thiourea, urea, or guanidine (3a-c) with enaminones (6a-e), and a series from 3-substituted-2-imino-1,3,5-triazin-1(2H)-yl-sulfonyl-phenyl-1-methylquinazoline-2,4(1H,3H)-dione (12a-j) were obtained from the reaction of N-(diaminomethylene)-4-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)benzenesulfonamide (11) with the enaminone (6a-j). The antitumor activity of the synthesized compounds was evaluated against two human cell lines: human colon carcinoma HCT116 and human hepatocellular carcinoma HEP-G2. Some of the tested compounds showed significant potency compared to the reference drug staurosporin.

On the hydrazinolysis of 3-aryl-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolines and their derivatives. Synthesis of compounds with aminoguanidine structure. VII

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