23976-56-9Relevant academic research and scientific papers
Cu (I) Catalyzed One Pot SN-Click Reactions of Halogenated Coumarins and 1-aza-coumarins
Revankar, Hrishikesh M.,Kulkarni, Manohar V.
, p. 537 - 544 (2018/01/10)
A one pot three component, copper catalyzed azide-alkyne cycloaddition reaction has been employed for the synthesis of bis-coumarinyl triazoles (A–D) using 4-chloro, 4-bromomethyl, 3-bromoacetyl and 4-bromomethyl-1-aza-coumarins (I–IV), sodium azide, and coumarin propargyl ethers (V–IX) in moderate yields.
Click chemistry approach for the regioselective synthesis of iso-indoline-1,3-dione-linked 1,4 and 1,5 coumarinyl 1,2,3-triazoles and their photophysical properties
Anand, Ashish,Kulkarni, Manohar V.
, p. 722 - 733 (2017/03/27)
Copper-catalyzed reaction of N-propargyl isoindoline-1,3-dione and 4-azidomethyl coumarins / 4-azidomethyl-1-aza coumarins under click chemistry conditions afforded 1,4-disubstituted 1,2,3-triazoles, whereas ruthenium catalysis yielded isomeric 1,5-disubstituted 1,2,3-triazoles. The two regioisomers have been distinguished by NOE studies. UV absorption for a given pair of isomers exhibited similar trend, whereas fluorescence measurements showed considerable differences. Photo physical studies on the interaction of azides with copper and ruthenium have also been performed.
Cyclopropanes in water: A diastereoselective synthesis of substituted 2H-chromen-2-one and quinolin-2(1H)-one linked cyclopropanes
Anand, Ashish,Yenagi, Jayashree,Tonannavar,Kulkarni, Manohar V.
, p. 2201 - 2205 (2016/04/19)
A one-pot three component reaction has been developed for the synthesis of substituted cyclopropanes employing 4-bromomethyl-2H-chromen-2-one/quinolin-2(1H)-ones, aromatic aldehydes and activated nitriles. The room temperature reaction in aqueous medium has been found to be diastereoselective and high yielding.
Synthesis and anti-bacterial evaluation of 4-aryloxymethyl carbostyrils derived from substructures and degradation products of Vancomycin
Revankar, Hrishikesh M.,Arali, Shweta,Yakkerimath, Shilpa,Revankar, Pooja P.,Naik, Vijaykumar,Anand, Ashish,Kulkarni, Manohar V.
, p. 637 - 642 (2017/01/18)
Vancomycin has been used as an antibiotic selectively against Gram-positive bacteria; however in the past decade they have grown resistant against it. The present work describes synthesis of a series of 4-aryloxymethyl carbostyrils derived from the reaction of 4-bromomethyl carbostryils with degradation products of Vancomycin (ethyl gallate and ethyl ester of N-benzoyl tyrosine ethyl ester). Further, gallate ethers 4a-d and tyrosine ethers 5a-d have been found to be selectively active against Gram-positive bacteria.
Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins
Kalkhambkar, Rajesh G.,Kulkarni, Geeta M.,Kamanavalli, Chandrappa M.,Premkumar,Asdaq,Sun, Chung Ming
experimental part, p. 2178 - 2188 (2009/04/07)
A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, 19F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein.
