23976-76-3

Usage

Uses

Used in Pharmaceutical Development:
2-(4-CHLOROBENZYLTHIO)-1H-BENZO[D]IMIDAZOLE is used as an active pharmaceutical ingredient for the development of new drugs due to its diverse biological activities and potential as an antimicrobial and antifungal agent.
Used in Antibiotic Development:
In the field of antibiotic research, 2-(4-CHLOROBENZYLTHIO)-1H-BENZO[D]IMIDAZOLE is used as a candidate for new antibiotics, given its demonstrated antimicrobial properties, which could contribute to addressing the growing concern of antibiotic resistance.
Used in Antifungal Agent Development:
Similarly, in antifungal research, 2-(4-CHLOROBENZYLTHIO)-1H-BENZO[D]IMIDAZOLE is utilized as a candidate for developing new antifungal agents, capitalizing on its antifungal capabilities to combat fungal infections.
Used in Anticancer Research:
2-(4-CHLOROBENZYLTHIO)-1H-BENZO[D]IMIDAZOLE is used as a subject of study in anticancer research for its potential to contribute to cancer treatment, based on the biological activities associated with its benzimidazole core structure.
Used in Anti-inflammatory and Antiviral Applications:
2-(4-CHLOROBENZYLTHIO)-1H-BENZO[D]IMIDAZOLE is also considered for use in anti-inflammatory and antiviral applications, as its core structure suggests potential benefits in these therapeutic areas, which could be further explored through research and development.

InChI:InChI=1/C14H11ClN2S/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2,(H,16,17)

Upstream product

• 583-39-1 2,3-dihydrobenzimidazol-2-thione 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 134469-07-1 Benzimidazol-2-thiol 
• 622-95-7 4-chlorobenzyl bromide 
• 95-54-5 1,2-diamino-benzene 

Relevant academic research and scientific papers

Design, synthesis and antitubercular activity of 2-(Benzylthio)-1H-benzo[d]imidazoles

Using molecular simplification and molecular hybridization approaches, a series of 2-(benzylthio)-1H-benzo[d]imidazoles was synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (M. tuberculosis) growth. Compounds 6p and 6z were c

The activity of magnesium/aluminum 'memory effect' reconstructed hydrotalcites in the microwave-assisted synthesis of 2-benzimidazolethiol and its alkylated derivatives

An efficient and practical methodology for the microwave-assisted synthesis of 2-benzimidazolethiol from 1,2-benzenediamine and carbon disulfide using reconstructed hydrotalcite is described. The corresponding mono- and dialkylated derivatives of 2-benzimidazolethiol were obtained generally in good to excellent yields after short reaction times. Reconstructed hydrotalcite proved to be an efficient and reusable heterogeneous base for the alkylation reactions. Georg Thieme Verlag Stuttgart New York.

Synthesis and preliminary evaluation of benzimidazole derivatives as antimicrobial agents

A series of 2-alkylsulphanylbenzimidazoles was synthesised and the compounds were evaluated for their in vitro antimicrobial activity. The structures of the compounds were confirmed by 1H-NMR and IR data, and their purity by elemental analysis. Antimycobacterial activities against Mycobacterium tuberculosis and non-tuberculous mycobacteria as well as antifungal activities against Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Trichosporon beigelii, Trichophyton mentagrophytes and Aspergillus fumigatus were expressed as the corresponding MIC values. The substances exhibited appreciable antimycobacterial activity, in particular, against non-tuberculous mycobacteria. The activity of the most active compound in the set, 3,5-dinitro derivative 4t, exceeded that of the standard isoniazide against M. kansasii and M. avium. The antifungal activities of the compounds were relatively low. A weak antifungal effect was observed against the dermatophyte Trichophyton mentagrophytes. None of the compounds showed significant inhibitory activity against yeasts.