23985-81-1

Usage

Uses

Used in Organic Synthesis:
Dibenzo[b,d]thiophene-4-carbaldehyde is used as a research compound in the field of organic synthesis. Its unique structure and reactivity make it a valuable building block for the development of new organic molecules and materials. The compound can be utilized in the synthesis of various complex organic molecules, including pharmaceuticals, agrochemicals, and advanced materials.
Used in Pharmaceutical Research:
In the pharmaceutical industry, dibenzo[b,d]thiophene-4-carbaldehyde is used as a key intermediate in the development of novel therapeutic agents. Its chemical properties allow for the creation of new drug candidates with potential applications in treating various diseases and medical conditions.
Used in Material Science:
Dibenzo[b,d]thiophene-4-carbaldehyde also finds applications in the field of material science, where it can be used to develop new materials with specific properties. These materials can be utilized in various industries, such as electronics, energy, and environmental protection, due to their unique characteristics.

InChI:InChI=1/C13H8OS/c14-8-9-4-3-6-11-10-5-1-2-7-12(10)15-13(9)11/h1-8H

Upstream product

• 7372-88-5 4-methyldibenzothiophene 
• 108847-20-7 4-dibenzothiophene boronic acid 
• 298-12-4 Glyoxilic acid 
• 132-65-0 dibenzothiophene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 87643-02-5 4-(o-carboxybenzyl)dibenzothiophene 
• 87643-03-6 4-(2-hydroxymethylbenzyl)dibenzothiophene 

Relevant academic research and scientific papers

Systematic structure-activity relationship (SAR) exploration of diarylmethane backbone and discovery of a highly potent novel uric acid transporter 1 (URAT1) inhibitor

In order to systematically explore and better understand the structure-activity relationship (SAR) of a diarylmethane backbone in the design of potent uric acid transporter 1 (URAT1) inhibitors, 33 compounds (1a-1x and 1ha-1hi) were designed and synthesized, and their in vitro URAT1 inhibitory activities (IC50) were determined. The three-round systematic SAR exploration led to the discovery of a highly potent novel URAT1 inhibitor, 1h, which was 200-and 8-fold more potent than parent lesinurad and benzbromarone, respectively (IC50 = 0.035 μM against human URAT1 for 1h vs. 7.18 μM and 0.28 μM for lesinurad and benzbromarone, respectively). Compound 1h is the most potent URAT1 inhibitor discovered in our laboratories so far and also comparable to the most potent ones currently under development in clinical trials. The present study demonstrates that the diarylmethane backbone represents a very promising molecular scaffold for the design of potent URAT1 inhibitors.

Base Catalysis Enables Access to α,α-Difluoroalkylthioethers

A nucleophilic addition reaction of aryl thiols to readily available β,β-difluorostyrenes provides α,α-difluoroalkylthioethers. The reaction proceeds through an unstable anionic intermediate, prone to eliminate fluoride and generate α-fluorovinylthioethers. However, the use of base catalysis overcomes the facile β-fluoride elimination, generating α,α-difluoroalkylthioethers in excellent yields and selectivities.

Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid

Reported herein is a conceptually novel organocatalytic strategy for the formylation of boronic acids. New reactivity is engineered into the α-amino-acid-forming Petasis reaction occurring between aryl boronic acids, amines, and glyoxylic acids to prepare aldehydes. The operational simplicity of the process and its ability to generate structurally diverse and valued aryl, heteroaryl, and α,β-unsaturated aldehydes containing a wide array of functional groups, demonstrates the practical utility of the new synthetic strategy.

AROMATIC HETEROCYCLIC COMPOUND, MANUFACTURING METHOD THEREOF, ORGANIC SEMICONDUCTOR MATERIAL, AND ORGANIC SEMICONDUCTOR DEVICE

Provided are an organic semiconductor material having a high charge mobility, oxidation stability, and solvent solubility, an organic semiconductor device using the same, and a novel aromatic heterocyclic compound to be used for the same and a production

Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives

The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder ("ADHD"), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.

Conformationally restricted diamines as spacers for parallel β-sheet formation

The dibenzofuran-based diamide 4,6-bis(N-acyl-aminomethyl)dibenzofuran is shown by 1H NMR and IR to have favourable geometry for intramolecular hydrogen bonding. The corresponding dibenzothiophene-based diamide 4,6-bis(N-acyl-aminomethyl)dibenzothiophene does not fulfill the geometric requirements for intramolecular hydrogen bonding. The intramolecularly hydrogen bonded state of the dibenzofuran-based diamide la is found to be 1 ± 0.5 kcal/mol more favoured enthalpically and 4 ± 2 cal/(K·mol) disfavoured entropically than the non-hydrogen bonded state.

The Synthesis of Benzophenathrothiophenes and Anthrabenzothiophenes

The synthesis of benzophenanthrothiophene (5), benzophenanthrothiophene (6), benzophenanthrothiophene (9), benzophenanthrothiophene (14a), anthrabenzothiophene (24), anthrabenzothiophene (29) and anthrabenzothiophene (30) is described as well as the preparation of 13-methylbenzophenanthrothiophene (14b).