23994-22-1Relevant academic research and scientific papers
Synthesis and nucleophilic reactions of cyano substituted N-methoxyisoquinolinium salts
Heber,Holzgrabe,Werra
, p. 785 - 790 (1993)
Starting from isoquinoline, the cyano substituted N-methoxyisoquinolinium salts 1.1 and 1.4 are prepared. Their behaviour in the presence of O-, C- and N-nucleophiles in different aprotic solvents is examined: from the 1-cyano substituted isoquinolinium derivative 1.1, 1- and 3-aminals or 1-iminium salts are obtained depending on the amine used, and N-methoxyisocarbostyril 4.1.1 in H2O and OH-. The reaction of the 4-cyano-N-methoxyisoquinolinium salt 1.4 with amines yields 1-aminals and with OH- the corresponding hemiaminal. Conversion with CN- results in dinitrile derivatives and N-oxides.
