24006-62-0 Usage
Description
Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); ) that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1-phosphate (d18:1) . In S. cerevisiae, the amount of sphinganine (d20:0) increases 10.8-fold in response to heat stress, indicating it is involved in heat stress adaptation. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers. Sphinganine can block protein kinase C activation in some cases but not others. [Matreya, LLC. Catalog No. 1845]
Uses
Sphinganine-C20 is a sphingolipid that plays an important role in the regulation of central cellular processes, including cell growth, survival and differentiation.
Definition
ChEBI: A 2-aminoicosane-1,3-diol having (2S,3R)-configuration.
Check Digit Verification of cas no
The CAS Registry Mumber 24006-62-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,0,0 and 6 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 24006-62:
(7*2)+(6*4)+(5*0)+(4*0)+(3*6)+(2*6)+(1*2)=70
70 % 10 = 0
So 24006-62-0 is a valid CAS Registry Number.
24006-62-0Relevant articles and documents
A general, efficient and stereospecific route to sphingosine, sphinganines, phytosphingosines and their analogs
Cai, Ye,Ling, Chang-Chun,Bundle, David R.
, p. 1140 - 1146 (2008/02/03)
Sphingosine, sphinganines and phytosphingosines and their analogs were synthesized by an aldol condensation between an iminoglycinate bearing a (+)-(1R,2R,5R)-2-hydroxy-3-pinanone group as chiral auxiliary and an appropriate aldehyde. All condensations proceeded with excellent enantioselectivity to generate the (2S,3R)-d-erythro structures in good yields. The Royal Society of Chemistry 2006.
