24006-92-6

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Dichloro-1,2-benzenedimethanol is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable building block in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 4,5-dichloro-1,2-benzenedimethanol is utilized as a precursor in the production of various agrochemicals, such as pesticides and herbicides. Its chemical properties contribute to the effectiveness of these products in controlling pests and promoting crop growth.
Used in Cosmetic and Personal Care Products:
4,5-Dichloro-1,2-benzenedimethanol is used as a preservative in cosmetic and personal care products due to its antimicrobial properties. It helps maintain the product's stability and prevents the growth of harmful microorganisms, ensuring the safety and efficacy of the products.
Used in Organic Compounds Synthesis:
As a versatile chemical intermediate, 4,5-dichloro-1,2-benzenedimethanol is used in the synthesis of various organic compounds for different applications, such as dyes, plastics, and other specialty chemicals. Its unique structure and reactivity make it a valuable component in the development of new materials and products.

InChI:InChI=1/C8H8Cl2O2/c9-7-1-5(3-11)6(4-12)2-8(7)10/h1-2,11-12H,3-4H2

Upstream product

• 942-06-3 4,5-dichlorophthalic anhydride 
• 56962-08-4 4,5-dichlorophthalic acid 
• 106727-86-0 4,5-dichlorophthalic acid dimethyl ester 

Downstream Products

• 21903-56-0 1,2-bis(bromomethyl)-4,5-dichlorobenzene 
• 13209-33-1 4,5-dichlorobenzene-1,2-dicarbaldehyde 
• 130217-38-8 2-(((tert-butyldimethylsilyl)oxy)methyl)-4,5-dichlorobenzaldehyde 
• 130217-40-2 [1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,5-dichloro-phenyl]-meth-(E)-ylidene]-trimethylsilanylmethyl-amine 
• 130217-45-7 Dimethyl 2,5-Dihydro-1-benzyloxycarbonyl-2-(2-chloromethyl-4,5-dichlorophenyl)pyrrole-3,4-dicarboxylate 
• 130217-42-4 Dimethyl 2,5-Dihydro-1-benzyloxycarbonyl-2-<2-(t-butyldimethylsilyloxymethyl)-4,5-dichlorophenyl>pyrrole-3,4-dicarboxylate 
• 872181-18-5 (4,5-dichloro-2-methoxymethoxymethylphenyl)methanol 
• 280134-99-8 4-formyl-1-(4,5-dichloro-2-hydroxymethylbenzyl)-indole 
• 1316054-11-1 (E)-4,5-dichloro-2-[(2-hydroxy-3-nitrocyclohex-2-en-1-yliden)methyl]benzaldehyde 
• 1379772-67-4 (6,7-dichloro-3-phenylnaphthalen-2-yloxy)triisopropylsilane 
• 872181-19-6 2-(4,5-dichloro-2-methoxymethoxymethylbenzyloxy)-6-fluorobenzonitrile 
• 1092448-42-4 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-dichloro-indan-2-carboxylic acid ethyl ester 
• 1092446-91-7 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-dichloro-indan-2-carboxylic acid 
• 24006-91-5 5,6-dichloroisobenzofuran-1(3H)-one 

Relevant academic research and scientific papers

2,3-Dihalo- and 2,3,6,7-Tetrahaloanthracenes by Vollhardt Trimerization

We efficiently synthesized otherwise difficult to obtain 2,3- and 2,3,6,7-halogenated anthracenes with diverse east/west substituents. Key steps involve the (i) Vollhardt cyclization of bis(propargyl)benzenes with bis(trimethylsilyl)acetylene, (ii) halo-desilylation introducing chlorine, bromine, or iodine substituents, and (iii) dehydrogenation. Pd catalysis allows selective functionalization at the anthracenes' east/west positions. A tetrahydropentacene is synthesized and derivatized via the same strategy, employing tetrapropargylbenzene.

A CATALYST FOR THE CARBONYLATION OF ALKENES

The present application relates to a metal complex of Formula (I) and a catalyst composition for the carbonylation of alkenes comprising the metal complex, wherein the metal is a group 10 element such as palladium, platinum or nickel, and the complex comprises a bidentate phosphine ligand. The present invention also relates to a process for the preparation of a dicarboxylic acid or ester thereof from an alkenoic acid or ester thereof, or a process for the preparation of a carboxylic acid or ester thereof from an alkene or alkenoic acid with high selectivity and activity using said metal complex or catalyst composition. The present application also relates to a method of preparing Nylon 6-6 comprising the step of copolymerising adipic acid with hexamethylenediamine.

Synthesis and optoelectronic properties of hexachloro- and hexaiodosubnaphthalocyanines as organic electronic materials

Chloroboron(III) hexachloro- and hexaiodosubnaphthalocyanines were prepared, and their solubility, electronic absorption spectroscopy, fluorescence emission spectroscopy and HOMO/LUMO energy levels were evaluated. These subnaphthalocyanines showed lower H

ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

Iron(II) pincer-catalyzed synthesis of lactones and lactams through a versatile dehydrogenative domino sequence

The synthesis of lactones and lactams by using iron(II) pincer-catalyzed dehydrogenative methodology was developed. Starting from 1,n-diols or 1,n-amino alcohols, this domino transformation takes place through initial dehydrogenation of the substrates, subsequent intramolecular cyclization, and final oxidation to afford the desired products in good yields. The ability to access heterocycles of different sizes makes this protocol especially versatile, in which two consecutive oxidation reactions are performed without requiring an external oxidant. In this paper, we report the application of the Fe-MACHO-BH complex [carbonylhydrido(tetrahydroborato)[bis(2-diisopropylphosphinoethyl)amino]iron(II)] in this atom-efficient and environmentally benign process, for which molecular hydrogen is formed as the only stoichiometric side product. Just a little pinch: The iron(II) pincer-catalyzed synthesis of lactones and lactams from easily available 1,n-diols and 1,n-amino alcohols is explored. The use of a nontoxic metal as well as the generation of molecular hydrogen as the only stoichiometric byproduct makes this method a highly atom-efficient and environmentally benign process.

Sc(OTf)3-Catalyzed [3 + 3] Cycloaddition of Cyclopropane 1,1-Diesters with Phthalazinium Dicyanomethanides

The Sc(OTf)3-catalyzed diastereoselective [3 + 3] cycloaddition of phthalazinium dicyanomethanides with cyclopropane 1,1-diesters proceeded smoothly under mild reaction conditions, affording a variety of 3,4-dihydro-1H-pyrido[2,1-a]phthalazine derivatives in up to 99% yields with excellent diastereoselectivities.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Substituted 5,6,11,12-tetradehydrodibenzo[ a, e ]cyclooctenes: Syntheses, properties, and DFT studies of substituted sondheimer-wong diynes

Highly strained cyclic acetylenes 5,6,11,12-tetradehydrodibenzo[a,e]cyclooctenes (Sondheimer-Wong diynes) having various substituents on their benzene rings were synthesized successfully by one-pot treatment of the corresponding formyl sulfones with diethyl chlorophosphate/lithium hexamethyldisilazide (LiHMDS) and then lithium diisopropylamide (LDA). When mixtures of two types of formyl sulfones bearing different substituents were subjected to this protocol, the unsymmetrically substituted Sondheimer-Wong diynes could be synthesized in a stepwise manner by isolation of the heterocoupled vinyl sulfone intermediates followed by their treatment with LDA. The UV-vis absorption spectra and cyclic voltammograms of the substituted Sondheimer-Wong diynes were recorded. The electronic effect of substituents on the diynes was investigated in their click reactions and nucleophilic and electrophilic additions.

Cobalt-Catalyzed Formal [4+2] Cycloaddition of α,α′-Dichloro-ortho-Xylenes with Alkynes

A formal [4+2] cycloaddition of α,α′-dichloro-ortho-xylenes with various alkynes has been developed using a low-valent cobalt catalyst. The transformation has a wide substrate scope and high functional-group tolerance and led to 1,4-dihydronaphthalenes. T

Cycloadditions of siloxy alkynes with 1,2-diazines: From reaction discovery to identification of an antiglycolytic chemotype

Cycloaddition uncovered: The title reaction produces novel polycyclic compounds with high efficiency and excellent diastereoselectivity under mild reaction conditions. A small-molecule library, synthesized using this reaction, yielded a novel chemotype which inhibited glycolytic ATP production by blocking glucose uptake in CHO-K1 cells. DMF=N,N-dimethylformamide, Tf= trifluoromethanesulfonyl, TIPS=triisopropylsilyl. Copyright