2401-25-4

Usage

Uses

Used in Chemical Synthesis:
4-CHLORO-3-IODOANISOLE is used as a synthetic intermediate for the production of various organic compounds. Its unique structure allows it to be a versatile building block in the synthesis of complex molecules.
Used in Pharmaceutical Industry:
4-CHLORO-3-IODOANISOLE is used as a key component in the development of new drugs. Its specific functional groups can be exploited to create novel therapeutic agents with potential applications in treating various diseases.
Used in Enantioselective Synthesis:
4-CHLORO-3-IODOANISOLE is used as a chiral auxiliary in enantioselective carbocycle formation through intramolecular Pd-catalyzed allyl-aryl cross-coupling. This application is particularly relevant in the synthesis of enantiomerically pure compounds, which are essential in the pharmaceutical industry due to their potential for improved efficacy and reduced side effects.
Used in Material Science:
4-CHLORO-3-IODOANISOLE can be used as a component in the development of new materials with specific properties. Its unique structure may contribute to the creation of materials with tailored characteristics for various applications, such as in electronics, coatings, or adhesives.

InChI:InChI=1/C7H6ClIO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,1H3

Upstream product

• 89694-46-2 2-chloro-5-methoxyphenylboronic acid 
• 766-85-8 3-methoxy-1-iodobenzene 
• 2401-24-3 2-chloro-5-methoxyaniline 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 

Downstream Products

• 202982-72-7 4-chloro-3-iodophenol 
• 1061316-80-0 2-(2-chloro-5-methoxyphenylthio)-1-(pent-4-ynyl)-1H-imidazo[4,5-c]pyridin-4-amine 
• 1400704-12-2 (S)-2-({2-[3-(2-chloro-5-methoxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester 
• 1400704-48-4 (S)-2-({2-[3-(2-chloro-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 
• 1168155-58-5 N-(2-chloro-5-methoxyphenyl)-2-nitro-3-(trifluoromethyl)aniline 
• 1095510-18-1 1-chloro-4-methoxy-2-phenylethynyl-benzene 
• 608131-09-5 [1-(2-chloro-5-methoxy-benzyl)-pentyl]-p-tolyl-amine 
• 608131-10-8 tert-butyl-[1-(2-chloro-5-methoxy-benzyl)-pentyl]-amine 

Relevant academic research and scientific papers

PYRIMIDINE AMIDE COMPOUNDS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.

FUSED AMINO PYRIDINE AS HSP90 INHIBITORS

The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of HSP90 related diseases and disorders such as cancer, an autoimmune disease, or a neurodegenerative disease.

Dehalogenation of o-dihalogen substituted arenes and α,α′-dihalogen substituted o-xylenes with lanthanum metal

It was found that lanthanum metal caused the dehalogenation of o-dihalogen substituted arenes and α,α′-dihalogen substituted o-xylenes to generate the corresponding benzynes and o-quinodimethanes. When o-dihalogen substituted arenes were allowed to react with lanthanum metal in the presence of dienes, the Diels-Alder products between benzyne and dienes were formed in moderate to good yields. Similarly, the Diels-Alder adducts of o-quinodimethane with dienophiles were obtained, in the reaction of α,α′-dibromo-o-xylenes with lanthanum metal in the presence of dienophiles.