24010-75-1

Upstream product

• 108-91-8 cyclohexylamine 
• 10191-60-3 dimethyl N-cyanodithioiminocarbonate 

Downstream Products

• 24010-79-5 1-Cyclohexyl-2-cyano-guanidin 
• 60178-42-9 1-cyclohexyl-2-methyl-3-(3-phenyl-[1,2,4]oxadiazol-5-yl)-isothiourea 
• 60178-48-5 1-cyclohexyl-2-methyl-3-[3-(4-nitro-phenyl)-[1,2,4]oxadiazol-5-yl]-isothiourea 
• 79183-81-6 2-cyclohexylamino-4-imino-4,5-dihydrothiazole 
• 1402084-78-9 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-cyclohexyl-1-piperidinecarboximidamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.

Synthesis and bactericidal activity of some symmetrical bisthioalkyl derivatives

The paper deals with the synthesis of some bactericides.The dithioacetal required are obtained by the reaction of active methylene compounds and aryl sulphonamides with carbon disulphide in alkaline conditions and subsequent alkylation with dimethyl sulphate.These compounds are then reacted with various pharmacopohores.All the compounds show moderate to significant activity with few compounds showing very high broad spectrum activity.

DIAMINOTHIAZOLES AND DIAMINOTHIOPHENES

Several 2,4-diaminothiazoles and 2,4-diaminothiophenes could be easily obtained by metallation using LDA from aminomethylthiomethylenecyanamides 2 and aminomethylthiomethylenemalononitrile, respectively.