240129-21-9

Usage

Uses

Used in Chemical Industry:
25,26,26,26,27,27,27-heptafluoro-5α,6α-epoxycholestanol is used as a chemical intermediate for the synthesis of other fluorinated compounds. Its unique reactivity and properties make it a valuable building block in the development of new chemical products.
Used in Pharmaceutical Industry:
25,26,26,26,27,27,27-heptafluoro-5α,6α-epoxycholestanol is used as a starting material for the development of new pharmaceutical drugs. Its unique structure and properties can be leveraged to create novel therapeutic agents with improved efficacy and selectivity.
Used in Drug Delivery Systems:
25,26,26,26,27,27,27-heptafluoro-5α,6α-epoxycholestanol can be employed as a component in drug delivery systems to enhance the solubility, stability, and bioavailability of pharmaceutical compounds. Its fluorinated nature may provide advantages in terms of lipophilicity and membrane permeability.
Used in Diagnostic Imaging:
25,26,26,26,27,27,27-heptafluoro-5α,6α-epoxycholestanol can be utilized as a contrast agent in diagnostic imaging techniques, such as magnetic resonance imaging (MRI) or computed tomography (CT). The presence of fluorine atoms may enhance the imaging contrast and provide better visualization of specific tissues or structures.
Used in Environmental Applications:
25,26,26,26,27,27,27-heptafluoro-5α,6α-epoxycholestanol can be employed in environmental remediation processes, such as the degradation of pollutants or the removal of heavy metals from contaminated water sources. Its unique chemical properties may facilitate the breakdown or sequestration of harmful substances.

Upstream product

• 240129-22-0 5,6β-epoxy-25,26,26,26,27,27,27-heptafluorocholest-5β-cholestan-3β-ol acetate 
• 153463-19-5 25,26,26,26,27,27,27-heptafluorocholest-5-en-3β-ol acetate 

Relevant academic research and scientific papers

Sterol synthesis. Preparation and characterization of fluorinated and deuterated analogs of oxygenated derivatives of cholesterol

Oxygenated sterols, including both autoxidation products and sterol metabolites, have many important biological activities. Identification and quantitation of oxysterols by chromatographic and spectroscopic methods is greatly facilitated by the availability of authentic standards, and deuterated and fluorinated analogs are valuable as internal standards for quantitation. We describe the preparation, purification and characterization of 43 oxygenated sterols, including the 4β-hydroxy, 7α-hydroxy, 7β-hydroxy, 7-keto, and 19-hydroxy derivatives of cholesterol and their analogs with 25,26,26,26,27,27,27-heptafluoro (F7) and 26,26,26,27,27,27-hexadeuterio (d6) substitution. The 7α-hydroxy, 7β-hydroxy, and 7-keto derivatives of (25R)-cholest-5-ene-3β,26-diol (1d) and their 16,16-dideuterio analogs were also prepared. These d2-26-hydroxysterols and [16,16-2H2]-(25R)-cholest-5-ene-3β,26-diol (1e) were synthesized from [16,16-2H2]-(25R)-cholest-5-ene-3β,26-diol diacetate (2e), which can be prepared from diosgenin. The highly specific deuterium incorporation at C-16 in 1e and 2e should be useful in mass spectral analysis of 26-hydroxycholesterol samples by isotope dilution methods. The Δ5-3β,7α,26- and Δ5-3β,7β,26-triols were regioselectively oxidized/isomerized to the corresponding Δ4-3-ketosteroids with cholesterol oxidase. Also described are 5,6α-epoxy-5α-cholestan-3β-ol, its 5β,6β-isomer, cholestane-3β,5α,6β-triol, their F7 and d6 derivatives, and d3-25-hydroxycholesterol, which was prepared from 3β-acetoxy-27-norcholest-5-en-25-one (30). The 43 oxysterols and most synthetic intermediates were isolated in high purity and characterized by chromatographic and spectroscopic methods, including mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Detailed mass spectral assignments are presented, and 1H NMR stereochemical assignments are derived for the C-19 protons of 19-hydroxysterols and for the side chain protons of 30. Copyright (C) 1999 Elsevier Science Ireland Ltd.