2402-96-2

Usage

Uses

Used in Chemical Synthesis:
4-Acetylpyridine N-Oxide is used as a reagent for chemical synthesis, enabling the production of various compounds and materials.
Used in Pharmaceutical Production:
4-Acetylpyridine N-Oxide is used as a starting material in the production of various pharmaceuticals, contributing to the development of new drugs and medications.
Used in Agrochemical Production:
4-Acetylpyridine N-Oxide is used as a starting material in the production of agrochemicals, aiding in the development of agricultural products and solutions.
Used as a Catalyst in Organic Reactions:
4-Acetylpyridine N-Oxide is used as a catalyst to facilitate and enhance the efficiency of various organic reactions, improving the synthesis process and yield of desired products.
Used in Material Science:
4-Acetylpyridine N-Oxide is used as a building block in the development of new materials, contributing to advancements in material properties and applications.
Used in Medicine:
4-Acetylpyridine N-Oxide has potential applications in the field of medicine, where it can be utilized in the development of new therapeutic agents and treatments.
Used in Agriculture:
4-Acetylpyridine N-Oxide has potential applications in agriculture, where it can be used in the development of agrochemicals for crop protection and enhancement.
It is important to handle and store 4-Acetylpyridine N-Oxide with care to prevent any potential hazards and ensure its proper usage in various industrial processes.

InChI:InChI=1/C7H7NO2/c1-6(9)7-2-4-8(10)5-3-7/h2-5H,1H3

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 14906-55-9 4-ethylpyridine-1-oxide 
• 143813-70-1 Perfluoro-cis-2-n-butyl-3-n-propyloxaziridine 
• 143813-73-4 Perfluoro-cis-2-n-hexyl-3-n-pentyloxaziridine 

Downstream Products

• 1122-54-9 methyl (4-pyridyl) ketone 
• 124300-44-3 1-(2-Phenylethynyl-pyridin-4-yl)-ethanone 
• 23794-15-2 1-(2-chloropyridin-4-yl)ethan-1-one 
• 1186331-97-4 (3R)-N-{4-[3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]pyridin-2-yl}quinuclidin-3-amine 
• 1186334-39-3 7-(2-chloropyridin-4-yl)-3-(3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine 
• 1186334-38-2 3-(3-methoxyphenyl)-7-(1-oxidopyridin-4-yl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidine 
• 52689-18-6 4-acetyl-2-pyridinecarbonitrile 

Relevant academic research and scientific papers

Visible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes

The photocatalyzed ortho-selective migration on a pyridyl ring has been achieved for the site-selective trifluoromethylative pyridylation of unactivated alkenes. The overall process is initiated by the selective addition of a CF3 radical to the alkene to provide a nucleophilic alkyl radical intermediate, which enables an intramolecular endo addition exclusively to the ortho-position of the pyridinium salt. Both secondary and tertiary alkyl radicals are well-suited for addition to the C2-position of pyridinium salts to ultimately provide synthetically valuable C2-fluoroalkyl functionalized pyridines. Moreover, the method was successfully applied to the reaction with P-centered radicals. The utility of this transformation was further demonstrated by the late-stage functionalization of complex bioactive molecules.

Visible Light-Mediated Decarboxylative Alkylation of Pharmaceutically Relevant Heterocycles

A net redox-neutral method for the decarboxylative alkylation of heteroarenes using photoredox catalysis is reported. Additionally, this method features the use of simple, commercially available carboxylic acid derivatives as alkylating agents, enabling the facile alkylation of a variety of biologically relevant heterocyclic scaffolds under mild conditions.

Hydroheteroarylation of Unactivated Alkenes Using N-Methoxyheteroarenium Salts

We report the first reductive coupling of unactivated alkenes with N-methoxy pyridazinium, imidazolium, quinolinium, and isoquinolinium salts under hydrogen atom transfer (HAT) conditions, and an expanded scope for the coupling of alkenes with N-methoxy pyridinium salts. N-Methoxy pyridazinium, imidazolium, quinolinium, and isoquinolinium salts are accessible in 1-2 steps from the commercial arenes or arene N-oxides (25-99%). N-Methoxy imidazolium salts are accessible in three steps from commercial amines (50-85%). In total 36 discrete methoxyheteroarenium salts bearing electron-donating, electron-withdrawing, alkyl, aryl, halogen, and haloalkyl substituents were prepared (several in multigram quantities) and coupled with 38 different alkenes. The transformations proceed under neutral conditions at ambient temperature, provide monoalkylation products exclusively, and form a single alkene addition regioisomer. Preparatively useful and complementary site selectivities in the addition of secondary and tertiary radicals to pyidinium salts are documented: harder secondary radicals favor C-2 addition (2->10:1), while softer tertiary radicals favor bond formation to C-4 (4.7->29:1). A diene possessing a 1,2-disubstituted and 2,2-disubstituted alkene undergoes hydropyridylation at the latter exclusively (61%) suggesting useful site selectivities can be obtained in polyene substrates. The methoxypyridinium salts can also be employed in dehydrogenative arylation, borono-Minisci, and tandem arylation processes. Mechanistic studies support the involvement of a radical process.

METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF

Compounds of formula A: Formula (1) pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.

Pharmacologically active pyridine derivatives and processes for the preparation thereof

N-phenyl-2-pyrimidineamine derivatives of formula I STR1 wherein the substituents are as defined in claim 1 and the derivatives of formula I can be used, for example, in the treatment of tumour diseases.

Formation of the N-oxides of heteroaromatic nitrogen compounds by perfluorinated oxaziridines

On treatment with perfluoro-cis-2,3-dialkyloxaziridines, mono-, bi-, and tricyclic nitrogen heteroaromatics afford the corresponding N-oxides under mild reaction conditions and in medium to high yields. The course of the reaction is not altered by the presence of various residues on the ring or in side chains and the N-oxides of polyfunctional, naturally occurring compounds have been prepared.

An Excellent Method for the Mild and Safe Oxidation of N-Heteroaromatic Compounds and Tertiary Amines

Selective, mild and safe N-oxidation of N-heteroaromatic compounds and tertiary amines affording high product yields was achieved by using the H2O2-urea/phthalic anhydride system. Key Words: N-Oxidation / Hydrogen peroxide / Urea / Phthalic anhydride