2402-98-4

Basic information

• Product Name: pyridine-2-carbonitrile 1-oxide
• Synonyms: pyridine-2-carbonitrile 1-oxide;2-Pyridinecarbonitrile 1-oxide;1-oxidopyridin-1-ium-2-carbonitrile;2-carbonitrilepyridine 1-oxide
• CAS NO: 2402-98-4
• Molecular Formula: C₆H₄N₂O
• Molecular Weight: 120.10876
• EINECS: 219-286-5
• Mol File: 2402-98-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 123-124 °C
• Boiling Point: 382.7°Cat760mmHg
• Flash Point: 185.3°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 4.63E-06mmHg at 25°C
• Refractive Index: 1.567
• PKA: -1.92±0.10(Predicted)
• CAS DataBase Reference: pyridine-2-carbonitrile 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: pyridine-2-carbonitrile 1-oxide(2402-98-4)
• EPA Substance Registry System: pyridine-2-carbonitrile 1-oxide(2402-98-4)

Safety Data

• Hazardous Substances Data: 2402-98-4(Hazardous Substances Data)

Usage

General Description

Pyridine-2-carbonitrile 1-oxide is a chemical compound with the molecular formula C6H4N2O. It is a nitrogen-containing heterocyclic compound that contains a pyridine ring and a nitrile group. The 1-oxide functionality indicates the presence of an oxygen atom attached to the first position of the pyridine ring. pyridine-2-carbonitrile 1-oxide is used in various chemical reactions and synthesis processes, and it has potential applications in pharmaceuticals and agrochemicals. It is important to handle pyridine-2-carbonitrile 1-oxide with caution, as it may have hazardous properties and should be used in a controlled and safe manner.

InChI:InChI=1/C6H4N2O/c7-5-6-3-1-2-4-8(6)9/h1-4H

Upstream product

• 1452-77-3 pyridine-2-carboxylic acid amide 
• 24145-26-4 (Z)-2-pyridinecarbaldehyde 1-oxide oxime 
• 6974-72-7 2-pyridinecarboxamide 1-oxide 
• 100-70-9 2-Cyanopyridine 

Downstream Products

• 65370-37-8 picolinic acid amidoxime N-oxide 
• 65370-37-8 2-(N'-hydroxycarbamimidoyl)pyridine 1-oxide 
• 1367127-60-3 C₂₀H₁₇FN₂O₄ 
• 1367127-58-9 C₂₀H₁₅FN₂O₃ 
• 1367127-56-7 C₂₀H₁₃FN₂O 
• 1127563-71-6 6-(4-(4-fluorophenoxy)phenyl)-4-chloropyridine-2-carbonitrile 
• 1367126-66-6 C₂₄H₂₃FN₄O₂ 
• 1367124-88-6 6-(4-(4-fluorophenoxy)phenyl)-4-((2-morpholinoethyl)amino)picolinamide 
• 1127562-03-1 C₁₃H₁₀N₂O 
• 1127561-99-2 C₁₅H₁₂N₂O₃ 
• 1127562-01-9 C₁₃H₁₀N₂O₂ 
• 1127563-68-1 6-(4-(4-fluorophenoxy)phenyl)pyridine-2-carbonitrile N-oxide 
• 100-70-9 2-Cyanopyridine 
• 2893-33-6 pyridine-2,6-dinitrile 

Relevant articles and documents

Regioselective Three-Component Reaction of Pyridine N-Oxides, Acyl Chlorides, and Cyclic Ethers

A novel three-component reaction of pyridine N-oxides, acyl chlorides, and cyclic ethers is described. Treatment of an electron-deficient pyridine N-oxide with an acyl chloride in the presence of a cyclic ether at 25-50 °C leads to a substituted pyridine as a single regioisomer in up to 58% isolated yield. Isotopic-labeling experiments and substrate scope support the reaction proceeding through a carbene intermediate.

Solvent- and halide-free synthesis of pyridine-2-yl substituted ureas through facile C-H functionalization of pyridine: N -oxides

A novel solvent- and halide-free atom-economical synthesis of practically useful pyridine-2-yl substituted ureas utilizes easily accessible or commercially available pyridine N-oxides (PyO) and dialkylcyanamides. The observed C-H functionalization of PyO is suitable for the good-to-high yielding synthesis of a wide range of pyridine-2-yl substituted ureas featuring electron donating and electron withdrawing, sensitive, or even fugitive functional groups at any position of the pyridine ring (63-92%; 19 examples). In the cases of 3-substituted PyO, the C-H functionalization occurs regioselectively providing a route for facile generation of ureas bearing a 5-substituted pyridine-2-yl moiety.

PYRIDINE COMPOUNDS AND THE USES THEREOF

The invention relates to substituted pyridine compounds of Formula (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, A1, A2, E, G, Z1, and Z2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.