2403-54-5

Basic information

• Product Name: 2-(4-Chlorophenyl)-1,3-dioxolane
• Synonyms: 2-(4-chlorophenyl)-1,3-dioxolane;1-(1,3-Dioxolane-2-yl)-4-chlorobenzene;2-(p-Chlorophenyl)-1,3-dioxolane;4-Chlorobenzaldehyde ethylene acetal;1,3-Dioxolane, 2-(4-chlorophenyl)-;1,3-Dioxolane, 2-(p-chlorophenyl)-;Nsc202824
• CAS NO: 2403-54-5
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.62
• Mol File: 2403-54-5.mol
• Article Data: 55

Chemical Properties

• Boiling Point: 267.8 °C at 760 mmHg
• Flash Point: 112.6 °C
• Appearance: /
• Density: 1.256 g/cm³
• Vapor Pressure: 0.0132mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 2-(4-Chlorophenyl)-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-1,3-dioxolane(2403-54-5)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-1,3-dioxolane(2403-54-5)

Safety Data

• Hazardous Substances Data: 2403-54-5(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)-1,3-dioxolane, also known as Dioxolane, is a chemical compound with the molecular formula C8H7ClO2. It is a colorless liquid with a sweet odor, commonly used as a solvent and in the manufacturing of pharmaceuticals and agrochemicals. Dioxolane is also used as an intermediate in the synthesis of other organic compounds. It is important to handle this chemical with care as it may cause skin and eye irritation upon contact. Furthermore, it is important to take proper safety precautions when working with this compound, as prolonged or repeated exposure may lead to harmful effects on health.

InChI:InChI=1/C9H9ClO2/c10-8-3-1-7(2-4-8)9-11-5-6-12-9/h1-4,9H,5-6H2

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 107-21-1 ethylene glycol 
• 111-90-0 ethoxyethoxyethanol 
• 39184-66-2 (4-chlorophenyl)chlorodiazirine 
• 265134-89-2 1-(1,3-dioxolan-2-yl)-1H-1,2,3-benzotriazole 
• 22391-05-5 2-(4-chlorophenyl)-1,3-oxathiolane 
• 107-07-3 2-chloro-ethanol 
• 122-51-0 orthoformic acid triethyl ester 
• 7381-30-8 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane 
• 1200-15-3 2-(4-chloro-benzyloxy)-ethanol 

Downstream Products

• 92-88-6 4,4'-Dihydroxybiphenyl 
• 66-98-8 4,4'-diformylbiphenyl 
• 100980-82-3 4’-hydroxy-[1,1‘-biphenyl]-4-carbaldehyde 
• 623-03-0 4-Cyanochlorobenzene 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 19824-38-5 ethylene glycol mono(4'-chlorobenzoate) 
• 106-43-4 para-chlorotoluene 
• 622-08-2 2-Benzyloxyethanol 
• 1200-15-3 2-(4-chloro-benzyloxy)-ethanol 
• 108-88-3 toluene 
• 873-76-7 para-Chlorobenzyl alcohol 
• 3848-36-0 4-chlorobenzaldoxime 
• 74-11-3 para-chlorobenzoic acid 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

Application of poly(Vinylbenzyltrimethylammonium tribromide) resin as an efficient polymeric catalyst in the acetalization and diacetylation of benzaldehydes

The applications of a new supported tribromide reagent (poly(vinylbenzyltrimethylammonium tribromide) resin) were reported. This supported tribromide resin was used as a catalyst in the acetalization and diacetylation of benzaldehydes under mild conditions with high efficiency. The effects of solvents, and amount of the supported tribromide resin on the reactions were investigated. Under the optimal conditions, most of acetal and 1,1-diacetates of benzaldehydes were selectively obtained in excellent yields.

Highly regioselective α-formylation and α-acylation of BODIPY dyes via tandem cross-dehydrogenative coupling with in situ deprotection

A metal-free C-H formylation and acylation of BODIPY dyes using a variety of dioxolane derivatives as aldehyde equivalents is reported, providing a postfunctionalization method for controllable synthesis of BODIPYs with carbonyl groups at 3,5-positions vi

Chemoselective Nucleophilic Functionalizations of Aromatic Aldehydes and Acetals via Pyridinium Salt Intermediates

The development of a novel chemoselective functionalization can diversify the strategy for synthesizing the target molecules. The perfect chemoselectivity between aromatic and aliphatic aldehydes is difficult to achieve by the previous methods. The aromatic aldehyde-selective nucleophilic addition in the presence of aliphatic aldehydes was newly accomplished. Namely, the aromatic aldehyde-selective nucleophilic addition using arenes and allyl silanes proceeded in the presence of trialkylsilyl triflate and 2,2′-bipyridyl, while the aliphatic aldehydes completely remained unchanged. The reactive pyridinium-type salt intermediate derived from an aromatic aldehyde chemoselectively underwent the nucleophilic substitution. Moreover, the aromatic acetals as the protected aldehydes could be directly transformed into similar pyridinium salt intermediates, which reacted with various nucleophiles coexisting with the aliphatic aldehydes.