24031-70-7Relevant academic research and scientific papers
3-Aryl-4-(2,6-dimethylbenzylidene)isoxazol-5(4H)-ones as Fungicides
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Page/Page column 22, (2012/03/27)
The invention relates to 3-aryl-4-(2,6-dimethylbenzylidene)isoxazol-5(4H)-ones, to agrochemically active salts thereof, to the use thereof and to methods and compositions for controlling phytopathogenic harmful fungi and insects in and/or on plants or in
Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)
Nantermet, Philippe G,Barrow, James C.,Lundell, George F.,Pellicore, Janetta M.,Rittle, Kenneth E.,Young, MaryBeth,Freidinger, Roger M.,Connolly, Thomas M.,Condra, Cindra,Karczewski, Jerzy,Bednar, Rodney A.,Gaul, Stanley L.,Gould, Robert J.,Prendergast, Kris,Selnick, Harold G.
, p. 319 - 323 (2007/10/03)
The synthesis and biological evaluation of a series of nonpeptidic small molecule antagonists of the human platelet thrombin receptor (PAR-1) are described. Optimization of the 5-amino-3-arylisoxazole lead resulted in an approximate 100-fold increase in potency. The most potent of these compounds (54) inhibits platelet activation with IC50s of 90 nM against the thrombin receptor agonist peptide (TRAP) and 510 nM against thrombin as the agonist. Further, antagonist 54 fully blocks platelet aggregation stimulated by 1 nM thrombin for 10 min.
Synthesis of Benzopyranoisoxazol-4-ones from 2-Substituted Chromone-3-carboxylic Esters. A Reinvestigation of the Reaction of 3-Acetyl-4-hydroxycoumarins with Hydroxylamine. Synthesis of 4-(2-Hydroxybenzoyl)isoxazol-5-ones
Chantegrel, Bernard,Nadi, Abdel Ilah,Gelin, Suzanne
, p. 4419 - 4424 (2007/10/02)
A convenient method for the synthesis of ethyl 2-substituted chromone-3-carboxylates by the condensation of o-acetoxyaroyl chlorides with β-keto esters is described.These chromones are converted into the corresponding 4H-benzopyranoisoxazol-4-on
