24036-63-3

Basic information

• Product Name: 1-Phenyl-1H-[1, 2, 4]triazole-3-carboxylic acid
• Synonyms: 1-Phenyl-1H-[1, 2, 4]triazole-3-carboxylic acid
• CAS NO: 24036-63-3
• Molecular Formula: C₉H₇N₃O₂
• Molecular Weight: 189.17
• Mol File: 24036-63-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 439 °C at 760 mmHg
• Flash Point: 219.3 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 1.76E-08mmHg at 25°C
• Refractive Index: 1.673
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Phenyl-1H-[1, 2, 4]triazole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-1H-[1, 2, 4]triazole-3-carboxylic acid(24036-63-3)
• EPA Substance Registry System: 1-Phenyl-1H-[1, 2, 4]triazole-3-carboxylic acid(24036-63-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 24036-63-3(Hazardous Substances Data)

Usage

General Description

1-Phenyl-1H-[1,2,4]triazole-3-carboxylic acid is a chemical compound, classified under the group of organoheterocyclic compounds known as phenyltriazoles. It has a molecular formula C9H7N3O2 and is comprised of a phenyl group and triazole ring attached with a carboxylic acid group. This makes it a bifunctional compound, combining both acidic and basic properties. Phenyltriazoles, including 1-Phenyl-1H-[1,2,4]triazole-3-carboxylic acid, are known for their wide range of applications, such as their use in producing organic light-emitting diodes (OLEDs) and in organic synthesis due to their structural flexibility. However, there is not much information currently available regarding its toxicity or potential hazards.

InChI:InChI=1/C9H7N3O2/c13-9(14)8-10-6-12(11-8)7-4-2-1-3-5-7/h1-6H,(H,13,14)

Upstream product

• 62-53-3 aniline 
• 57226-96-7 methyl 1-phenyl-1H-1,2,4-triazole-3-carboxylate 
• 4928-88-5 methyl 1H-1,2,4-triazole-3-carboxylate 
• 98-80-6 phenylboronic acid 
• 2999-46-4 Ethyl isocyanoacetate 
• 1019-95-0 ethyl 1-phenyl-1H-1,2,4-triazole-3-carboxylate 
• 28663-68-5 ethyl (phenylhydrazono)chloroacetate 
• 61698-27-9 3-acetyl-1-phenyl-1,2,4-triazole 

Downstream Products

• 1443757-61-6 [4-(3-chloro-benzoyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]-triazol-3-yl)-methanone 
• 1443759-73-6 [2,2-dimethyl-4-(3-methylamino-4-nitro-benzoyl)-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]-triazol-3-yl)-methanone 
• 1443759-75-8 [4-(4-amino-3-methylamino-benzoyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone 
• 1443756-74-8 [4-(3-isopropyl-benzoyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone 
• 1443757-54-7 [4-(2-cyclopentylmethyl-3-methyl-3H-benzoimidazole-5-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]-triazol-3-yl)-methanone 
• 1443759-20-3 (2,2-dimethyl-piperazin-1-yl)-(1-phenyl-1-H-[1,2,4]-triazol-3-yl)-methanone trifluoroacetate 
• 1613021-67-2 (S)-1-phenyl-N-(1-(pyrazolo[1,5-a]pyrazin-4-yl)pyrrolidin-3-yl)-1H-1,2,4-triazole-3-carboxamide 
• 2518-43-6 (1-phenyl-1H-1,2,4-triazol-3-yl)methanol 
• 1613021-84-3 (S)-N-(1-([1,2,4]triazolo[4,3-a]pyrazin-8-yl)pyrrolidin-3-yl)-1-phenyl-1H-1,2,4-triazole-3-carboxamide 
• 1613021-48-9 N-[(3S)-3-(hydroxymethyl)-1-imidazo[1,2-a]pyrazin-8-yl-pyrrolidin-3-yl]-1-phenyl-1,2,4-triazole-3-carboxamide 
• 1613021-45-6 N-[(3S)-3-(hydroxymethyl)-1-pyrrolo[1,2-a]pyrazin-1-yl-pyrrolidin-3-yl]-1-phenyl-1,2,4-triazole-3-carboxamide 
• 1613022-30-2 1-phenyl-1H-[1,2,4]triazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]amide 
• 1613021-92-3 (S)-N-(1-(imidazo[1,2-a]pyrazin-8-yl)pyrrolidin-3-yl)-1-phenyl-1H-1,2,4-triazole-3-carboxamide 
• 1613021-27-4 C₂₃H₂₅N₇O 

Relevant articles and documents

Design, synthesis and biological evaluation of glycolamide, glycinamide, and β-amino carbonyl 1,2,4-triazole derivatives as DPP-4 inhibitors

Through modification of the skeleton of Sitagliptin and Vildagliptin, we successfully synthesized and built-up four series of 1,2,4-triazole derivatives, containing N,O-disubstituted glycolamide, N,N′-disubstituted glycinamide, β-amino ester, and β-amino

PIPERAZINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLU5 RECEPTORS

This invention relates to compounds of formula (I) their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. R1, R2, R3, R4, Q have meanings given in the description.