24039-08-5

Basic information

• Product Name: 2,4-Imidazolidinedione, 1,3-dimethyl-
• Synonyms: 2,4-Imidazolidinedione, 1,3-dimethyl-;1,3-Dimethyl-2,4-imidazolidinedione;1,3-dimethylimidazolidine-2,4-dione
• CAS NO: 24039-08-5
• Molecular Formula: C₅H₈N₂O₂
• Molecular Weight: 128.13
• Mol File: 24039-08-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 44-45 °C
• Boiling Point: 169℃
• Flash Point: 62℃
• Appearance: /
• Density: 1.234
• Vapor Pressure: 1.54mmHg at 25°C
• Refractive Index: 1.502
• PKA: -1.88±0.20(Predicted)
• CAS DataBase Reference: 2,4-Imidazolidinedione, 1,3-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Imidazolidinedione, 1,3-dimethyl-(24039-08-5)
• EPA Substance Registry System: 2,4-Imidazolidinedione, 1,3-dimethyl-(24039-08-5)

Safety Data

• Hazardous Substances Data: 24039-08-5(Hazardous Substances Data)

Usage

Uses

1,3-Dimethyl-2,4-imidazolidinedione is used as a reactant in the preparation of [(indolyl)methyl]hydantoin and -thiohydantoin derivatives and study of their structure-activity relationship in treatment of necroptosis.

InChI:InChI=1/C5H8N2O2/c1-6-3-4(8)7(2)5(6)9/h3H2,1-2H3

Upstream product

• 461-72-3 2,4-imidazolidinedione 
• 74-88-4 methyl iodide 
• 111184-55-5 3,5-dimethylhydantoindimethylamide 
• 25017-51-0 (4-hydroxy-phenethyl)-urea 
• 3923-79-3 4,5-dihydroxy-1,3-dimethylimidazolidin-2-one 
• 1122-91-4 4-bromo-benzaldehyde 
• 854644-22-7 N-(2-acetylaminoethyl)-N'-phenylurea 
• 41613-26-7 1,3-dimethyl-5-nitrouracil 
• 58-68-4 NADH 

Relevant articles and documents

Unexpected formation of 4-alkyl-5-(4-alkylthiosemicarbazido)-4,5-dihydro-1, 2,4-triazine-3(2H)-thiones from 1,3-dialkyl-4,5-bis-(4-alkylthiosemicarbazido) imidazolidin-2-ones in acidic medium

4-Alkyl-5-(4-alkylthiosemicarbazido)-4,5-dihydro-1,2,4-triazine-3(2H) -thiones are obtained either by heating 1,3-dialkyl-4,5-bis-(4- alkylthiosemicarbazido)imidazolidin-2-ones in acidic medium or the reaction of 1,3-dialkyl-4,5-dihydroxyimidazolidin-2-on

4,5-Dihydroxyimidazolidin-2-ones in α-ureidoalkylation of N-carboxyalkyl-, N-hydroxyalkyl-, and N-(aminoalkyl)ureas 4.* α-Ureidoalkylation of N-(2-acetylaminoethyl)ureas

α-Ureidoalkylation of N-(2-acetylaminoethyl)ureas with various 4,5-dihydroxyimidazoli- din-2-ones was systematically studied. Novel N-(2-acetylaminoethyl)glycolurils were obtained. Their yields were found to decrease both when moving from 1,3-H2- to 1,3-Alk2-4,5- dihydroxy- imidazolidin-2-ones and when increasing the size of the substituent at the second N atom in the starting acetylaminoethylurea. The higher yields were achieved with 4,5-diphenyl-4,5- dihydroxyimidazolidin-2-one as the starting compound. 2-(2-Acetylaminoethyl)-4-methylgly- coluril exhibits nootropic activity.

4,5-Dihydroxyimidazolidin-2-ones in a-ureidoalkylation of N-carboxy-, N-hydroxy-, and N-aminoalkylureas 2. α-Ureidoalkylation of N-(hydroxyalkyl)ureas

sThe a-ureidoalkylation of N-(hydroxyalkyl)ureas (ureido alcohols) with 1,3-H3-and 1,3-Me2-4,5-dihydroxyimidazolidin-2-ones was systematically studied. The yields of glycolurils decrease both in going from 1,3-H2-to 1,3-Me2-4,5-dihydroxyimidazolidin-2-one and with increasing length (or with branching) of the hydroxyalkyl chain in ureido alcohols. The optimal reaction time for ureido alcohols is 1 h. The X-ray diffraction study showed that 2-(2-hydroxy-1,1-dimethylethyl)glycoluril crystallizes as a conglomerate. The enantiomeric analysis of 2-(2-hydroxyethyl)glycoluril was carried out by chiral-phase HPLC. ; 2009 Springer Science+Business Media, Inc.