240401-09-6

Basic information

• Product Name: N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL
• Synonyms: N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL ;tert-butyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate;1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester;8-Boc-3-hydroxy-1-oxa-8-azaspiro[4.5]decane
• CAS NO: 240401-09-6
• Molecular Formula: C₁₃H₂₃NO₄
• Molecular Weight: 257.32602
• Mol File: 240401-09-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 390.991 °C at 760 mmHg
• Flash Point: 190.265 °C
• Appearance: /
• Density: 1.16
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.34±0.20(Predicted)
• CAS DataBase Reference: N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL(240401-09-6)
• EPA Substance Registry System: N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL(240401-09-6)

Safety Data

• Hazardous Substances Data: 240401-09-6(Hazardous Substances Data)

Usage

General Description

N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL is a chemical compound with a spirocyclic structure containing oxygen and nitrogen atoms, as well as a BOC (tert-butoxycarbonyl) protecting group. Its molecular formula is C12H21NO4, and it is commonly used in organic synthesis and pharmaceutical research. The compound's spirocyclic nature gives it unique chemical and physical properties, making it useful in the development of new drugs and materials. It is also a versatile building block for the synthesis of various complex molecules, making it an important intermediate in chemical and medicinal chemistry.

InChI:InChI=1/C13H23NO4/c1-12(2,3)18-11(16)14-6-4-13(5-7-14)8-10(15)9-17-13/h10,15H,4-9H2,1-3H3

Upstream product

• 203662-51-5 1-(t-butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 954236-44-3 tert-butyl 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 
• 240401-08-5 tert-butyl 3-(benzyloxy)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 
• 757239-75-1 tert-butyl 1-oxa-8-azaspiro[4.5]dec-3-ene-8-carboxylate 

Downstream Products

• 898157-46-5 tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 
• 1227566-37-1 C₁₅H₁₈F₃NO₂ 
• 1227566-52-0 C₁₅H₁₈F₃NO 
• 1227566-40-6 C₁₄H₁₈ClNO 
• 1346515-36-3 C₂₀H₂₅N₃O₃ 
• 1227472-02-7 (3RS)-N-(3,4-dimethylisoxazol-5-yl)-3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxamide 
• 1346515-37-4 C₂₁H₂₄F₃N₃O₄ 
• 1227473-05-3 (3RS)-N-(3,4-dimethylisoxazol-5-yl)-3-[3-(trifluoromethyl)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxamide 
• 1346515-38-5 C₂₁H₂₄F₃N₃O₃ 
• 1227472-03-8 (3RS)-3-(3-chlorophenyl)-N-(3,4-dimethylisoxazol-5-yl)-1-oxa-8-azaspiro[4.5]decane-8-carboxamide 
• 1227472-04-9 (3RS)-3-(3,4-dichlorophenyl)-N-(3,4-dimethylisoxazol-5-yl)-1-oxa-8-azaspiro[4.5]decane-8-carboxamide 
• 1227472-17-4 (3RS)-3-(3-chloro-4-fluorophenyl)-N-(3,4-dimethylisoxazol-5-yl)-1-oxa-8-azaspiro[4.5]decane-8-carboxamide 
• 1346515-39-6 C₂₁H₂₄N₄O₃ 
• 1346515-40-9 C₂₁H₂₄N₄O₃ 

Relevant articles and documents

DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS

Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

HETEROCYCLIC SPIRO COMPOUNDS AS MAGL INHIBITORS

The present invention provides, in part, heterocyclic spiro compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or sa

1-OXA-8-AZASPIRO [4, 5 ] DECANE- 8 -CARBOXAMIDE COMPOUNDS AS FAAH INHIBITORS

Provided herein are 1-oxa-8-azaspiro[4.5]decane-8-carboxamide compounds of formula I wherein Ar1, Ar2, R1, R2, R3 and R4 are as defined herein and the pharmaceutically acceptable salts of such compounds useful in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, conditions including acute pain, chronic pain, neuropathic pain, nociceptive pain, inflammatory pain, fibromyalgia, rheumatoid arthritis, inflammatory bowel disease, lupus, diabetes, allergic asthma, vascular inflammation, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease.