240401-27-8

Basic information

• Product Name: 2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester
• Synonyms: 2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester;1,1-dimethylethyl 2-oxa-7-azaspiro[3,5]nonane-7-carboxylate;2-Oxa-7-azaspiro[3.5]nonane-7-carboxylicacid;2-oxa-7-azaspiro[3,5]nonane-7-carboxylic acid tert-butyl ester;tert-butyl 2-oxa-7-azaspiro[3.5]nonane-7-carboxylate;7-Boc-2-oxa-7-azaspiro[3.5]nonane, 95%;7-Boc-2-oxa-7-azaspiro[3....;2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-diMethylethyl
• CAS NO: 240401-27-8
• Molecular Formula: C₁₂H₂₁NO₃
• Molecular Weight: 227.31
• Mol File: 240401-27-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 31-70°C
• Boiling Point: 315.83 °C at 760 mmHg
• Flash Point: 144.809 °C
• Appearance: /
• Density: 1.10
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: ?20°C
• PKA: -0.80±0.20(Predicted)
• CAS DataBase Reference: 2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester(240401-27-8)
• EPA Substance Registry System: 2-Oxa-7-azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dimethylethyl ester(240401-27-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 240401-27-8(Hazardous Substances Data)

Usage

Uses

It is used as an active pharmaceutical intermediate.

InChI:InChI=1/C12H21NO3/c1-11(2,3)16-10(14)13-6-4-12(5-7-13)8-15-9-12/h4-9H2,1-3H3

Upstream product

• 765962-22-9 diethyl 1-benzylpiperidine-4,4-dicarboxylate 
• 848070-24-6 piperidine-4,4-diyldimethanol 
• 374794-84-0 tert-butyl 4,4-bis(hydroxymethyl)piperidine-1-carboxylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1126-09-6 4-carbethoxypiperidine 
• 848070-26-8 1-(tert-butyl) 4,4-diethyl piperidine-1,4,4-tricarboxylate 
• 374794-85-1 1,1-dimethylethyl 4-hydroxymethyl-4-methanesulfonyloxymethyl-1-piperidinecarboxylate 

Downstream Products

• 1313369-52-6 2-oxa-7-azaspiro[3,5]nonane acetic acid salt 
• 1313369-55-9 C₁₅H₁₉NO₃ 
• 1257381-44-4 C₂HF₃O₂*C₇H₁₃NO 
• 1290049-37-4 (S)-2-methyl-4-[4-(2-oxa-7-aza-spiro[3.5]non-7-yl)-4-oxo-butyl]-3-oxo-piperazine-1-carboxylic acid (3-chloro-phenyl)-amide 
• 374792-67-3 cis-(RS)- and trans-(RS)-α-methyl-N-{4-[4-hydroxymethyl-4-(methoxymethyl)piperidin-1-yl]-1-phenylcyclohexyl}-3,5-bis(trifluoromethyl)benzeneacetamide 

Relevant articles and documents

SUBSTITUTED OXAZOLIDINONES FOR THE TREATMENT OF MAMMALIAN INFECTIONS

Present invention relates to novel compound of formula (I), their enantiomers, their diastereomers, their pharmaceutically accepted salts, or pro-drugs thereof, which are useful for the treatment of bacterial infection.

An improved synthesis of 2-oxa-7-azaspiro[3,5]nonane and analogs as novel reagents in medicinal chemistry

A detailed synthesis of novel spirocyclic oxetane analogs is described for the first time.