240423-23-8

Basic information

• Product Name: 8-(3,4-Dihydroxy-4-methylpentyl)-3-isopropyl-7-methylnaphthalene-1,2-dione
• Synonyms: 8-(3,4-Dihydroxy-4-methylpentyl)-3-isopropyl-7-methylnaphthalene-1,2-dione;8-(3,4-Dihydroxy-4-methylpentyl)-7-methyl-3-(1-methylethyl)-1,2-naphthalenedione
• CAS NO: 240423-23-8
• Molecular Formula: C20H26O4
• Molecular Weight: 330
• Mol File: 240423-23-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 516.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• PKA: 14.62±0.29(Predicted)
• CAS DataBase Reference: 8-(3,4-Dihydroxy-4-methylpentyl)-3-isopropyl-7-methylnaphthalene-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(3,4-Dihydroxy-4-methylpentyl)-3-isopropyl-7-methylnaphthalene-1,2-dione(240423-23-8)
• EPA Substance Registry System: 8-(3,4-Dihydroxy-4-methylpentyl)-3-isopropyl-7-methylnaphthalene-1,2-dione(240423-23-8)

Safety Data

• Hazardous Substances Data: 240423-23-8(Hazardous Substances Data)

Usage

Uses

8-(3,4-Dihydroxy-4-methylpentyl)-3-isopropyl-7-methylnaphthalene-1,2-dione is useful in the synthesis of analogs which exhibits potent cytotoxicity against tumor cells and topoisomerase II inhibitory effects.

Upstream product

• 102607-41-0 4,5-seco-5,10-friedo-Abieta-3,5⁽¹⁰⁾,6,8,13-pentaene-11,12-dione 
• 240423-22-7 8-[2-(3,3-dimethyl-oxiranyl)-ethyl]-3-isopropyl-7-methyl-[1,2]naphthoquinone 

Relevant articles and documents

Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis

From the roots of Salvia prionitis a new tricyclic diterpene, saprirearine (1), a new anhydride-type compound, saprionide (2), a new 7,8-seco-abietane diterpene derivative, 7,8-seco-para-ferruginone (3), and two new 4,5-seco-5,10-friedo-abietane diterpeno

Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs

A novel diterpenequinone named salvicine (4), structurally modified derivative of a natural product, and a series of the novel analogs have been prepared. Most of the analogs were found to be potently active against tumor cell lines in vitro. Further study on 4 in vivo demonstrated that it possessed a significant antineoplastic activity against murine S-180 Sarcoma and Lewis lung cancer, and human lung adenocarcinoma xenografts A-549 and LAX-83. The preclinical studies of 4 are now under way.