240483-57-2Relevant academic research and scientific papers
Dual-acting agents with α1-adrenoceptor antagonistic and steroid 5α- reductase inhibitory activities. Synthesis and evaluation of arylpiperazine derivatives
Sato, Hiroki,Kitagawa, Osamu,Aida, Yoshiyuki,Chikazawa, Jun,Kurimoto, Tadashi,Takei, Mineo,Fukuta, Yoshihisa,Yoshida, Kiyoshi
, p. 1553 - 1558 (2007/10/03)
A series of arylpiperazine derivatives were prepared and evaluated for their α1-adrenoceptor antagonistic activities and 5α-reductase inhibitory activities. SAR study led to the identification of the potent dual-acting compound 2f, which had a pA2 value of 7.5 for α1-adrenoceptor antagonism and an IC50 value of 1.5 nM for 5α-reductase inhibition.
