240494-25-1

Upstream product

• 4767-03-7 2,2-bis(hydroxymethyl)propionic acid 
• 408322-03-2 2,2,5-trimethyl-1,3-dioxane-5-carboxylic anhydride 
• 853178-43-5 2,2'-disulfanediylbis(ethane-2,1-diyl) bis(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate) 
• 853178-42-4 2,2'-disulfanediylbis(ethane-2,1-diyl) bis(2,2,5-trimethyl-1,3-dioxane-5-carboxylate) 

Relevant academic research and scientific papers

Accelerated growth of dendrimers via thiol-ene and esterification reactions

By taking advantage of the orthogonal nature of thiol-ene coupling and anhydride based esterification reactions, a facile and chemoselective strategy to dendritic macromolecules has been developed. The ability to interchange growth steps based on thiol-ene and anhydride chemistry allows the synthesis of fifth-generation dendrimers in only five steps and under benign reaction conditions. In addition, the presented coupling chemistries eliminate the traditional need for protection/deprotection steps and afford dendrimers in high yield and purity. The modularity of this strategy coupled with the latent reactivity of the alkene/hydroxyl chain ends was demonstrated by using different cores (alkene and hydroxyl functional), various AB2 and CD 2 monomers and a range of chain end groups. As a result, three dendritic libraries were prepared which exhibited tunability of both the chemical functionality and physical properties including the fabrication of PEG hydrogels.

Accelerated Chemoselective Reactions to Sequence-Controlled Heterolayered Dendrimers

Chemoselective reactions are a highly desirable approach to generate well-defined functional macromolecules. Their extraordinary efficiency and selectivity enable the development of flawless structures, such as dendrimers, with unprecedented structure-to-property capacity but with typically tedious synthetic protocols. Here we demonstrate the potency of chemoselective reactions to accomplish sequence-controlled heterolayered dendrimers. An accurate accelerated design of bis-MPA monomers with orthogonally complementary moieties and a wisely selected chemical toolbox generated highly complex monodisperse dendrimers through simplified protocols. The versatility of the strategy was proved by obtaining different dendritic families with different properties after altering the order of addition of the monomers. Moreover, we evaluated the feasibility of the one-pot approach toward these heterolayered dendrimers as proof-of-concept.