240495-14-1

Basic information

• Product Name: dioctyl 2-[[(4,4'-dimethoxytrityl)oxy]methyl]-2-(hydroxymethyl)malonate
• Synonyms: dioctyl 2-[[(4,4'-dimethoxytrityl)oxy]methyl]-2-(hydroxymethyl)malonate
• CAS NO: 240495-14-1
• Molecular Weight: 690.918
• Mol File: 240495-14-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dioctyl 2-[[(4,4'-dimethoxytrityl)oxy]methyl]-2-(hydroxymethyl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: dioctyl 2-[[(4,4'-dimethoxytrityl)oxy]methyl]-2-(hydroxymethyl)malonate(240495-14-1)
• EPA Substance Registry System: dioctyl 2-[[(4,4'-dimethoxytrityl)oxy]methyl]-2-(hydroxymethyl)malonate(240495-14-1)

Safety Data

• Hazardous Substances Data: 240495-14-1(Hazardous Substances Data)

Upstream product

• 16958-88-6 dioctyl malonate 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 183206-14-6 dioctyl 2,2-bis(hydroxymethyl)malonate 

Relevant articles and documents

Solid support synthesis of ester linked hydrophobic conjugates of oligonucleotides

Novel non-nucleosidic phosphoramidite building block 2 was employed for multiple modification of oligonucleotides with hydrophobic octyl groups. Hydrophobic sites are attached via potentially biodegradable ester bonds that are demonstrated to withstand the conditions of DNA deprotection. The chimeric oligonucleotides are capable of forming triple helix complexes that are stabilized by forming a hydrophobic clamp consisting of terminal octyl groups.