24068-46-0

Upstream product

• 562-46-9 4,4-dimethylcyclohexane-1,3-dione 
• 563-80-4 3-methyl-butan-2-one 
• 1609011-31-5 3-amino-6,6-dimethylcyclohex-2-en-1-one potassium salt 
• 2034-43-7 4,4-dimethyl-5-oxohexane-nitrile 

Downstream Products

• 121049-66-9 4-(2-Chlorophenyl)-3-ethoxycarbonyl-6,6-dimethyl-2-[2-(2-methylbenzimidazol-1-yl) ethoxymethyl]-1,4,5,6,7,8-hexahydro-5-oxoquinoline 

Relevant academic research and scientific papers

FUSED PYRIDINE AND PYRIMIDINE DERIVATIVES AS ROR GAMMA MODULATORS

The present invention provides fused pyridine and pyrimidine derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which Ra, Rb, A, B, X, P, Q, L, R4, R5 and m

Cyclization of cyanoethylated ketones as a route to 6-substituted indole derivatives

δ-Cyanoketones are quickly cyclized with KOtBu to 3-aminocyclohex-2-enone derivatives, which in turn will give substituted indoles when treated with oxalyl chloride. Thus, 3-amino-6,6-dimethylcyclohex-2-enone gave 3-chloro-6,6-dimethyl-2,5,6,7-tetrahydroindole-2,5-dione, whose structure was corroborated by X-ray crystallography, whereas the corresponding molecule without the blocking gem-dimethyl groups, 3-aminocyclohex-2-enone, gave via hydrogen shifts 6-chloro-3-hydroxyoxindole.

Facile diversity-oriented synthesis and antitubercular evaluation of novel aryl and heteroaryl tethered pyridines and dihydro-6H-quinolin-5-ones derived via variants of the Bohlmann-Rahtz reaction

The diversity oriented synthesis of substituted pyridines and dihydro-6H-quinolin-5-ones tethered with aryls and heteroaryls was achieved in very good yields through CeCl3?7H2O-NaI catalyst via variants of the Bohlmann-Rahtz reaction

TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable a salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group

TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I

TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The invention relates to tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGIuR modulators an