240820-01-3Relevant academic research and scientific papers
6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES
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Page 19, (2008/06/13)
The present invention provides novel compounds of formula (I) wherein R is selected from the group consisting of R2, R2NH-, or H2N-R3- wherein R2 is selected from the group consisting of C1-C8 alkyl and formula (II), wherein Z is selected from the group c
Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717
Dreyer,Borcherding,Dumont,Peet,Tsay,Wright,Bitonti,Shen,Kim
, p. 524 - 530 (2007/10/03)
Cyclin-dependent kinases (CDKs) are regulatory proteins of the eukaryotic cell cycle. They act after association with different cyclins, the concentrations of which vary throughout the progression of the cell cycle. As central mediators of cell growth, CD
