24083-16-7Relevant articles and documents
New double-chain and aromatic (α-hydroxyalkyl)phosphorus amphiphiles
Brun, Alice,Etemad-Moghadam, Guita
, p. 1385 - 1390 (2002)
New double-chain bis-(α-hydroxyalkyl)phosphinic acids 1 are synthesized from NaH2PO2·H2O and aliphatic aldehydes. Direct and quantitative one-pot synthesis of new 4-alkoxybenzaldehydes 2 is realized from 1-bromoalkanes and
Bodipy-based photosensitizers with long alkyl tails at the meso position: efficient singlet oxygen generation in Cremophor-EL micelles
Kilic, Bilal,Yesilgul, Nisa,Polat, Veli,Gercek, Zuhal,Akkaya, Engin U.
, p. 1317 - 1320 (2016)
Bodipy dyes with n-decyloxyphenyl-(4, 5) and pentadecyl-(8) meso substituents can easily embed themselves into micellar structures formed from Cremophor-EL. In micelles of approximately 20 nm median size, heavy-atom substituted dyes show remarkable photos
A pH-responsive superamphiphile based on dynamic covalent bonds
Wang, Chao,Wang, Guangtong,Wang, Zhiqiang,Zhang, Xi
, p. 3322 - 3325 (2011)
Under pH control: A successful example of a toothbrush-type superamphiphile based on dynamic covalent bonds is demonstrated. The superamphiphile can self-assemble in water to form spherical aggregates, which disassemble reversibly under mildly acidic cond
Giant domain formation in a thin film of bisstyrylanthracene derivatives by a simple melt process
Konishi, Misuzu,Fujita, Katsuhiko,Tsutsui, Tetsuo
, p. 11 - 19 (2004)
Bisstyrylanthracene derivatives with long alkyl side chains (BSA), which were prepared into the thin films composed of giant anisotropic domains by simple melt process, showed interesting property. The derivatives that changed the chains length and chains
Highly packed and stretched polyterpyridinyl Ru2+ complexes and their photophysical and stability properties
Liu, Die,Jiang, Zhilong,Wang, Meng,Yang, Xiaoyu,Liu, Haisheng,Wu, Tun,Wang, Pingshan
, p. 293 - 298 (2016)
Two unique trinuclear terpyridine-ruthenium complexes having similar components placed at different angels were successfully synthesized and fully characterized for the purpose of determining the photophysical and electronic properties. The corresponding
Synthesis, mesomorphism, photophysics and device performance of liquid-crystalline pincer complexes of gold(iii)
Parker, Rachel R.,Liu, Denghui,Yu, Xiankang,Whitwood, Adrian C.,Zhu, Weiguo,Williams,Wang, Yafei,Lynam, Jason M.,Bruce, Duncan W.
supporting information, p. 1287 - 1302 (2021/02/12)
Emissive gold(iii) complexes of pincer 2,6-diphenylpyridines also bearing a phenylacetylide ligand have been modified at both the pincer and phenylacetylide to confer liquid crystalline properties, with most complexes showing a columnar hexagonal phase in
Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors
Li, Hao,Sibley, Christopher D.,Kharel, Yugesh,Huang, Tao,Brown, Anne M.,Wonilowicz, Laura G.,Bevan, David R.,Lynch, Kevin R.,Santos, Webster L.
, (2021/01/07)
The sphingosine 1-phosphate (S1P) signaling pathway is an attractive target for pharmacological manipulation due to its involvement in cancer progression and immune cell chemotaxis. The synthesis of S1P is catalyzed by the action of sphingosine kinase 1 or 2 (SphK1 or SphK2) on sphingosine and ATP. While potent and selective inhibitors of SphK1 or SphK2 have been reported, development of potent dual SphK1/SphK2 inhibitors are still needed. Towards this end, we report the structure–activity relationship profiling of 2-(hydroxymethyl)pyrrolidine-based inhibitors with 22d being the most potent dual SphK1/SphK2 inhibitor (SphK1 Ki = 0.679 μM, SphK2 Ki = 0.951 μM) reported in this series. 22d inhibited the growth of engineered Saccharomyces cerevisiae and decreased S1P levels in histiocytic lymphoma myeloid cell line (U937 cells), demonstrating inhibition of SphK1 and 2 in vitro. Molecular modeling studies of 22d docked inside the Sph binding pocket of both SphK1 and SphK2 indicate essential hydrogen bond between the 2-(hydroxymethyl)pyrrolidine head to interact with aspartic acid and serine residues near the ATP binding pocket, which provide the basis for dual inhibition. In addition, the dodecyl tail adopts a “J-shape” conformation found in crystal structure of sphingosine bound to SphK1. Collectively, these studies provide insight into the intermolecular interactions in the SphK1 and 2 active sites to achieve maximal dual inhibitory activity.
Novel organic semiconductors based on 2-amino-anthracene: Synthesis, charge transport and photo-conductive properties
Blach, J. F.,Boussoualem, Y.,Carlescu, I.,Danjou, P.,Daoudi, A.,Duponchel, B.,Hurduc, N.,Kondratenko, K.,Legrand, C.,Simion, A.
, p. 13885 - 13894 (2021/07/07)
Anthracene is considered to be a popular choice as a building block for organic semiconductors. The present work is dedicated to the synthesis and characterization of a novel semiconductor (10-OPIA) possessing mesogenic properties, which allows better con
Aggregation-induced emissions in the mesogenic BF2complexes of aroylhydrazines
Cai, Yi-Hong,Chih, Hsin-Yun,Lai, Chung K.,Lee, Gene-Hsiang
, p. 12557 - 12568 (2021/07/25)
Herein, we report the synthesis of two new families of borondifluoride complexes derived from aroylhydrazines and the investigation of their mesomorphic and AIE properties. The crystallographic structure of the mesogenic complex1a-BF2(n= 8) was
1,3-Oxazine-2-one derived dual-targeted molecules against replicating and non-replicating forms of Mycobacterium tuberculosis
Velappan, Anand Babu,Kesamsetty, Dhanunjaya,Datta, Dhrubajyoti,Ma, Rui,Hari, Natarajan,Franzblau, Scott G.,Debnath, Joy
supporting information, (2020/10/02)
The high mortality rate and increasing prevalence of resistant Mtb are the major concerns for the Tuberculosis (TB) treatment in this century. To curtail the prevalence of resistant Mtb, we have prepared 1,3-oxazine-2-one based dual targeted molecules. Compound 67 and 68 were found to be equally active against replicating and non-replicatiing form of Mtb (MICMABA 3.48 and 2.97 μg/ml; MICLORA 2.94 and 2.15 μg/ml respectively). They had found to suppress the biosynthesis of alfa, methoxy and keto-mycolate completely, as well as inhibit enzymatic activity of MenG (IC50 = 9.11 and 6.25 μg/ml respectively for H37Ra; IC50 = 11.76 and 10.88 μg/ml respectively for M smegmatis).
