24085-05-0

Basic information

• Product Name: 1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE
• Synonyms: 1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE;3'-CHLOROMETHYL-4'-HYDROXYACETOPHENONE;Ethanone, 1-[3-(chloromethyl)-4-hydroxyphenyl]-;1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE(WXG00080)
• CAS NO: 24085-05-0
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.62
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 24085-05-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 160 °C (decomp)
• Boiling Point: 363.6 °C at 760 mmHg
• Flash Point: 173.7 °C
• Appearance: Red solid
• Density: 1.255 g/cm³
• Vapor Pressure: 8.52E-06mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly), DMSO (Sparingly), Methanol (Slightly)
• PKA: 7.58±0.48(Predicted)
• CAS DataBase Reference: 1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE(24085-05-0)
• EPA Substance Registry System: 1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE(24085-05-0)

Safety Data

• Hazardous Substances Data: 24085-05-0(Hazardous Substances Data)

Usage

Chemical Properties

Red Solid

Uses

3-Chloromethyl-4-hydroxyacetophenone (cas# 24085-05-0) is a compound useful in organic synthesis.

Preparation

Preparation by introduction of the chloromethyl group into 4-hydroxyacetophenone by treatment with formaldehyde and hydrochloric acid, in the presence of zinc chloride [Blanc (Chloromethylation) reaction],92%.

InChI:InChI=1/C9H9ClO2/c1-6(11)7-2-3-9(12)8(4-7)5-10/h2-4,12H,5H2,1H3

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 50-00-0 formaldehyd 

Downstream Products

• 30392-64-4 1-(4-acetoxy-3-chloromethyl-phenyl)-ethanone 
• 107699-87-6 O,O-dimethyl-S-(3-acetyl-6-hydroxybenzyl)phosphorodithioate 
• 65236-06-8 5-acetyl-2-hydroxyphenylacetonitrile 
• 107700-05-0 5-(ω,ω-dibromoacetyl)-3-bromo-2-hydroxybenzyl chloride 
• 107700-04-9 5-(ω-bromoacetyl)-3-bromo-2-hydroxybenzyl chloride 
• 107724-60-7 5-acetyl-3-bromo-2-hydroxybenzyl chloride 
• 93344-88-8 Thiophosphoric acid O-{4-acetyl-2-[(diisopropylamino)-methyl]-phenyl} ester O',O''-diethyl ester 
• 92041-43-5 1-{4-hydroxy-3-[(morpholin-4-yl)methyl]phenyl}ethan-1-one 
• 92500-17-9 1-{4-hydroxy-3-[(piperidin-1-yl)methyl]phenyl}ethan-1-one 
• 39235-57-9 4-hydroxy-3-acetyloxymethylacetophenone 
• 104450-62-6 1-(3-Methoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone 
• 104450-65-9 1-(3-Butoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone 
• 104450-78-4 1-(4-Oxiranylmethoxy-3-propoxymethyl-phenyl)-ethanone 
• 104450-63-7 1-(3-Ethoxymethyl-4-oxiranylmethoxy-phenyl)-ethanone 

Relevant articles and documents

CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE

The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.

Synthesis and Biological Evaluation of New Combined α/β-Adrenergic Blockers

The synthesis, characterization, and pharmacological evaluation of new aryloxyaminopropanol compounds based on substituted (4-hydroxyphenyl)ethanone with alterations in the alkoxymethyl side chain in position 2 and with 2-methoxyphenylpiperazine in the ba

5-(1-Acetoxyvinyl)-cyclosaligenyl-2′,3′-dideoxy-2′, 3′- didehydrothymidine monophosphates, a second type of new, enzymatically activated cyclosaligenyl pronucleotides

In our attempt to further develop the cycloSal pronucleotide concept, we report on 5-(1-acetoxyvinyl)-cycloSal-d4TMPs as a new type of enzyme-activated pronucleotides. These compounds were converted into 5-acetyl-cycloSal-d4TMPs by (carboxy)esterase cleav