24091-68-7

Upstream product

• 31352-60-0 (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl phenylphosphinate 
• 104-88-1 4-chlorobenzaldehyde 
• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 659749-68-5 [(4-Chloro-phenyl)-hydroxy-methyl]-phenyl-phosphinic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 

Relevant academic research and scientific papers

Convenient synthesis of optically active α-hydroxyphosphinic acids

The reaction of O-menthyl phenylphosphonite 1 with aromatic aldehydes in the presence of Me3SiCl provided the O-menthyl α-hydroxy-phosphinates 2. Acidic hydrolysis of 2 gave the corresponding α-hydroxyphosphinic acids 3. The (+)-enantiomer of 3