2409479-29-2 Usage
Uses
Used in Pharmaceutical Industry:
1-(4-(1R)-1-[2-(6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-ylamino)pyridin-4-yl]ethylpiperazin-1-yl)-3,3,3-trifluoropropan-1-one is used as a potential candidate for drug development due to its complex structure and the presence of various functional groups that may contribute to pharmacological activity.
Used in Medicinal Chemistry Research:
1-(4-(1R)-1-[2-(6-[6-(dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-ylamino)pyridin-4-yl]ethylpiperazin-1-yl)-3,3,3-trifluoropropan-1-one serves as a subject of study in medicinal chemistry, where its structural features are analyzed for potential interactions with biological targets, such as enzymes or receptors, which could lead to the discovery of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 2409479-29-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,4,0,9,4,7 and 9 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2409479-29:
(9*2)+(8*4)+(7*0)+(6*9)+(5*4)+(4*7)+(3*9)+(2*2)+(1*9)=192
192 % 10 = 2
So 2409479-29-2 is a valid CAS Registry Number.
2409479-29-2Relevant academic research and scientific papers
Lefranc, Julien,Schulze, Volker Klaus,Hillig, Roman Christian,Briem, Hans,Prinz, Florian,Mengel, Anne,Heinrich, Tobias,Balint, Jozsef,Rengachari, Srinivasan,Irlbacher, Horst,St?ckigt, Detlef,B?mer, Ulf,Bader, Benjamin,Gradl, Stefan Nikolaus,Nising, Carl Friedrich,Von Nussbaum, Franz,Mumberg, Dominik,Panne, Daniel,Wengner, Antje Margret
, p. 601 - 612 (2020)
The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homologue IKK? are noncanonical members of the inhibitor of the nuclear factor κB (IκB) kinase family. These kinases play important roles in multiple cellular pathways and, in particular, in inflammation. Herein, we describe our investigations on a family of benzimidazoles and the identification of the potent and highly selective TBK1/IKK? inhibitor BAY-985. BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 and displays antiproliferative efficacy in the melanoma cell line SK-MEL-2 but showed only weak antitumor activity in the SK-MEL-2 human melanoma xenograft model.
