24095-60-1

Usage

Uses

Used in Biochemical Research:
3-Chlor-benzamidine hydrochloride is used as a protease inhibitor for its ability to bind to and inhibit the activity of serine proteases, which is crucial for studying the enzymatic activity of these proteins in various assays and experiments.
Used in Protease Assays:
In the field of protease assays, 3-Chlor-benzamidine hydrochloride is utilized as an essential component to control the activity of serine proteases, allowing for accurate measurements and analyses of their functions.
Used in Protease Purification and Characterization:
3-Chlor-benzamidine hydrochloride serves as a key reagent in the purification and characterization of proteases, facilitating the isolation of these enzymes and the elucidation of their properties and mechanisms of action.
Used in Laboratory Settings:
In laboratory settings, 3-Chlor-benzamidine hydrochloride is employed as a reagent to support a range of biochemical investigations, including the examination of protease functions and the development of related research methodologies.

InChI:InChI=1/C7H7ClN2.ClH/c8-6-3-1-2-5(4-6)7(9)10;/h1-4H,(H3,9,10);1H

Upstream product

• 56108-07-7 3-Chloro-benzimidic acid methyl ester; hydrochloride 
• 766-84-7 3-chloro-benzonitrile 
• 60612-87-5 ethyl 3-chlorobenzimidate hydrochloride 

Downstream Products

• 91272-17-2 2-(m-chlorophenyl)-5,6-pentamethylenepyrimidin-4(3H)-one 
• 91272-28-5 2-(m-chlorophenyl)-hexamethylenepyrimidin-4(3H)-one 
• 87753-09-1 2-(3-chlorophenyl)-3,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one 
• 87753-15-9 2-(3-Chloro-phenyl)-7-methyl-3,5,6,7-tetrahydro-cyclopentapyrimidin-4-one 
• 477879-44-0 N-{1-[3-(3-Chlorophenyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}acetamide 
• 882182-25-4 6-hydroxy-5-acetylmethyl-2-(3-chlorophenyl)-3H-pyrimidine-4-one 
• 26863-50-3 2-(3-chloro-phenyl)-1H-pyrimidine-4,6-dione 
• 100677-40-5 3,5-bis(3-chlorophenyl)-1H-1,2,4-triazole 
• 1613637-83-4 2,4-bis(3-chlorophenyl)-1,3,5-triazine 
• 87753-09-1 2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ol 

Relevant academic research and scientific papers

Facile synthesis of 3,5-diaryl-1,2,4-triazoles via copper-catalyzed domino nucleophilic substitution/oxidative cyclization using amidines or imidates as substrates

Two methods for the synthesis of 3,5-diaryl-1,2,4-triazoles, both domino reactions, are reported. The first procedure, the Cu(OTf)2-catalyzed reaction between two amidines using NaHCO3 as a base, 1,10-phenanthroline as an additive and K3[Fe(CN)6]/ atmospheric oxygen as the oxidant, delivers 3,5-diaryl-1,2,4-triazoles with yields up to 68%. The second procedure for the synthesis of 3,5-diaryl-1,2,4- triazoles with yields up to 64% rests on the Cu(OTf)2-catalyzed reaction between two imidates and ammonium carbonate. This method features the formation of three bonds in a single synthetic step.

HETEROARYL INHIBITORS OF PDE4

The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.

Preparation of Triazolopyrimidines as Potential Antiasthma Agents

With the use of the human basophil histamine release assay, 5-aryl-2-aminotriazolopyrimidines were found to be active as mediator release inhibitors.These compounds were prepared by reacting arylamidines with sodium ethyl formylacetate or with ethyl propiolate to give pyrimidinones.Treatment with phosphorus oxychloride gave a chloropyrimidine, which was converted to a hydrazinopyrimidine with hydrazine.Cyclization, using cyanogen bromide, gave the triazolopyrimidines, after a Dimroth rearrangement.Following a structure-activity evaluation, the5--2-amino (8-10), 5-(3-bromophenyl)-2-amino (8-13), 5--2-amino (8-11), and 5-(4-pyridinyl)-2-amino (6-7) compounds were found to have the best activity.They were chosen for further pharmacological and toxicological study.