24095-80-5

Usage

Classification

Organosulfur compound

Uses

Synthesis of pharmaceuticals and organic compounds

Properties

Potent antibacterial and antifungal

Structure

Contains hydrazine and carbothioamide moiety

Applications

Potential in pharmaceutical industry

Interest

Research and development purposes in medicinal chemistry

Upstream product

• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 
• 90475-89-1 3,5-di(trifluoromethyl)phenyldiazonium chloride 
• 886-35-1 3,5-bis(trifluoromethyl)phenylhydrazine 
• 556-61-6 methyl thioisocyanate 

Downstream Products

• 96406-84-7 3-methyl-4-phenyl-2-(3,5-bistrifluoromethylanilinoimino)-4-thiazoline hydrobromide 
• 96406-82-5 3-methyl-2-(3,5-bistrifluoromethylanilinoimino)thiazolidin-4-one 
• 96406-83-6 3,4-dimethyl-2-(3,5-bistrifluoromethylanilinoimino)-4-thiazoline hydrochloride 

Relevant academic research and scientific papers

Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides

Several 1-arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines have been examined for their antiimplantation activity in rats.Among the active compounds, 4-methyl-1-(3,5-bistrifluoromethylphenyl)thiosemicarbazide (3, C 2696-Go) and the corresponding 4,4-dimethyl (47), ethyl (4), n-butyl (5) and allyl (6) derivatives completely inhibit implantation at doses 10, 3, 20, 20 and 30 mg/kg respectively.The 3,4-dichlorophenyl analogue (32) is effective at a dose of 30 mg/kg. 2-(3,5-Bistrifluoromethylphenyl)hydrazinothiazoline (51) and the corresponding dihydrothiazine (63) show a weaker activity.The biological profile of C 2696-Go has been investigated in detail.It appears to prevent implantation by its antiuterotropic activity and ability to inhibit desiduoma formation.