24127-63-7

Upstream product

• 21770-48-9 methyl 2,3-dibromo-3-phenylpropanoate 
• 103-26-4 methyl cinnamate 
• 21770-49-0 methyl 2,3-dihydro-3-phenylbenzo[b][1,4]dioxine-2-carboxylate 

Downstream Products

• 1487273-91-5 3-(3-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)-methyl)piperazin-1-yl)propyl)-1H-indole 
• 1487273-93-7 5-fluoro-3-(3-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methyl)piperazin-1-yl)propyl)-1H-indole 
• 1487273-96-0 5-chloro-3-(3-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methyl)piperazin-1-yl)propyl)-1H-indole 
• 1487273-99-3 3-(3-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)-methyl)piperazin-1-yl)propyl)-5-methyl-1H-indole 
• 1487273-55-1 3-(2-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)-methyl)piperazin-1-yl)ethyl)-1H-indole 
• 1487273-57-3 5-fluoro-3-(2-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methyl)piperazin-1-yl)ethyl)-1H-indole 
• 1487273-59-5 5-chloro-3-(2-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methyl)piperazin-1-yl)ethyl)-1H-indole 
• 1487273-62-0 3-(2-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)-methyl)piperazin-1-yl)ethyl)-5-methyl-1H-indole 
• 1573402-81-9 C₁₉H₂₂N₂O₂ 
• 1573402-83-1 C₂₂H₂₀O₅S 
• 1596340-51-0 2-((4-bromobutoxy)methyl)-2,3-dihydro-3-phenyl-benzo[b][1,4]dioxane 
• 1596340-52-1 2-((5-bromopentyloxy)methyl)-3-phenyl-2,3-dihydrobenzo[b][1,4]dioxine 
• 1596340-50-9 2-((3-bromopropyloxy)methyl)-2,3-dihydro-3-phenylbenzo[b][1,4]dioxane 
• 1596340-62-3 2-(1-(5-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)pentyl)piperidin-4-yl)benzo[d]thiazole 

Relevant academic research and scientific papers

Synthesis and biological evaluation of a series of benzoxazole/ benzothiazole-containing 2,3-dihydrobenzo[b][1,4]dioxine derivatives as potential antidepressants

A series of benzoxazole/benzothiazole-2,3-dihydrobenzo[b][1,4]dioxine derivatives (5a-5d and 8a-8j) was synthesized. Compounds were evaluated for binding affinities at the 5-HT1A and 5-HT2A receptors. Antidepressant activities of the compounds were screened using the forced swimming test (FST) and the tail suspension test (TST). The results indicated that the compounds exhibited high affinities for the 5-HT1A and 5-HT2A receptors and showed a marked antidepressant-like activity. Compound 8g exhibited high affinities for the 5-HT1A (Ki = 17 nM) and 5-HT2A (Ki = 0.71 nM) receptors; it also produced a decrease of the immobility time and exhibited potent antidepressant-like effects in the FST and TST in mice.

Synthesis and evaluation of novel 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives as potential antidepressants

A series of 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives were synthesized and the target compounds were evaluated for their binding affinities at the 5-HT1A receptor and serotonin transporter. Antidepressant-like activities of the compounds were screened using the tail suspension and forced swim tests in mice. Preliminary results indicated that the target compounds exhibited high binding affinities at the 5-HT1A receptor and serotonin transporter, and produced marked antidepressant-like effects. The best example from this study, compound 5, exhibited high binding affinities for the 5-HT1A receptor (Ki = 96 nM) and serotonin transporter (Ki = 9.8 nM). The intrinsic activity of compound 5 showed agonistic property to the 5-HT1A receptor and inhibition of the 5-HT transporter. Furthermore, compound 5 exhibited greater antidepressant efficacy than fluoxetine and showed acceptable pharmacokinetic properties. A series of 3-(2-(4-((2,3-dihydrobenzo[b][1,4]dioxin-3-yl)methyl) piperazin-1-yl)ethyl-1H-indole derivatives were synthesized and the target compounds were evaluated for their antidepressant activities in vitro and in vivo. The compounds described were also evaluated for dual 5-HTT and 5-HT 1A receptor activities.