24134-09-6

Basic information

• Product Name: 5-BROMO-1,2-DIMETHYL-1H-IMIDAZOLE
• Synonyms: 4-BROMO-1,5-DIMETHYLIMIDAZOLE;5-BROMO-1,2-DIMETHYL-1H-IMIDAZOLE;1,2-Dimethyl-5-bromo-1H-imidazole;5-Bromo-1,2-dimethyl-1H-imidazole ,97%;5-broMo-1,2-diMethyliMidazole;1H-IMidazole,5-broMo-1,2-diMethyl-
• CAS NO: 24134-09-6
• Molecular Formula: C₅H₇BrN₂
• Molecular Weight: 175.03
• Product Categories: blocks;Bromides;Imidazoles
• Mol File: 24134-09-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 91 °C
• Boiling Point: 266.6°Cat760mmHg
• Flash Point: 115°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 0.0141mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: Keep Cold
• PKA: 5.93±0.25(Predicted)
• CAS DataBase Reference: 5-BROMO-1,2-DIMETHYL-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1,2-DIMETHYL-1H-IMIDAZOLE(24134-09-6)
• EPA Substance Registry System: 5-BROMO-1,2-DIMETHYL-1H-IMIDAZOLE(24134-09-6)

Safety Data

• Hazard Codes: C,Xn
• Statements: 22
• Hazardous Substances Data: 24134-09-6(Hazardous Substances Data)

Usage

General Description

5-Bromo-1,2-dimethyl-1H-imidazole, also known as BDIM, is a chemical compound with the formula C5H7BrN2. It is a heterocyclic compound containing both a bromine and a methyl group, and is commonly used as a pharmaceutical intermediate in the synthesis of pharmaceuticals. This chemical is also used as a building block in the production of agrochemicals and fine chemicals. Its unique structure and properties make it a valuable reagent in organic synthesis. As a reagent, it is used in the synthesis of various pharmaceuticals and organic compounds, making it an important component in the pharmaceutical and chemical industries.

InChI:InChI=1/C5H7BrN2/c1-4-7-3-5(6)8(4)2/h3H,1-2H3

Upstream product

• 16265-11-5 5-bromo-2-methyl-1H-imidazole 
• 80-48-8 methyl p-toluene sulfonate 
• 1739-84-0 1,2-dimethyl-1H-imidazole 
• 16265-11-5 4-bromo-2-methyl-1H-imidazole 
• 74-88-4 methyl iodide 
• 24021-93-0 (1,2-dimethyl-1H-imidazol-5-yl)methanol 

Downstream Products

• 1739-84-0 1,2-dimethyl-1H-imidazole 
• 1095274-60-4 methyl 3-chloro-5-(1,2-dimethyl-1H-imidazol-4-yl)benzoate 
• 1095274-61-5 methyl 3-chloro-5-(1,2-dimethyl-1H-imidazol-5-yl)benzoate 
• 1400287-81-1 4-(1,2-dimethyl-1H-imidazol-5-yl)aniline 
• 1400287-29-7 4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyaniline 
• 86051-75-4 1,2-dimethyl-5-(tributylstannyl)-1H-imidazole 
• 1578246-26-0 N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)formamide 
• 1578245-39-2 N²-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-6-methyl-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine 
• 1578244-07-1 N²-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-N⁸-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine 
• 1192574-86-9 2-{6-[({[(1,2-dimethyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}-1H-isoindole-1,3(2H)-dione 
• 1192575-00-0 6-[({[(1,2-dimethyl-1H-imidazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-amine 
• 1192576-00-3 1-(1,2-dimethyl-1H-imidazol-5-yl)-N-hydroxy-1-phenylmethanimine 
• 1201005-56-2 5-(4-tolyl)-1,2-dimethyl-1H-imidazole 

Relevant articles and documents

Mechanistic Studies on the Palladium-Catalyzed Direct C-5 Arylation of Imidazoles: The Fundamental Role of the Azole as a Ligand for Palladium

An in-depth mechanistic study on the palladium-catalyzed direct arylation of imidazoles at the C-5 position is presented. The interactions of triphenylphosphine (PPh3)-ligated aryl-Pd species with 1,2-dimethyl-1H-imidazole (dmim) have been studied in detail. In contrast with previous suggestions, phosphine-ligated organo-Pd species are not active and the reaction proceeds through imidazole-ligated organo-Pd intermediates. The kinetics of the oxidative addition of aryl halides with dmim-ligated Pd(0) species have been characterized in a Pd(dba)2/dmim model system. A thorough study of the equilibria involving novel [ArPd(dmim)2X] complexes (X=I, OAc) and the unexpected cationic [ArPd(dmim)3]+ is also reported. The ability of these species to effect the C-H arylation of dmim at room temperature in the presence of acetate is also demonstrated.

HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS

The present invention relates to novel compounds that are CGRP receptor antagonists, processes for their preparation, to compositions containing them and to their use in the treatment of migraine, headache, and cluster headache.